نتایج جستجو برای: transporter
تعداد نتایج: 49293 فیلتر نتایج به سال:
The ability of plants to grow and produce high yields in soils with low zinc (Zn) availability is different among wheat cultivars. However, the physiological mechanism behind Zn efficiency is not currently fully understood and the putative role of Zn transporter proteins in contributing to Zn efficiency has not yet been determined. Therefore, the aim of this study was to compare the expression ...
Therapeutic response to metformin, a first-line drug for type 2 diabetes (T2D), is highly variable, in part likely due to genetic factors. To date, metformin pharmacogenetic studies have mainly focused on the impact of variants in metformin transporter genes, with inconsistent results. To clarify the significance of these variants in glycemic response to metformin in T2D, we performed a large-s...
In this review we reported and discussed the structural features of the ATP-Binding Cassette (ABC) transporter ABCA3 and how the use of bioinformatics tools could help researchers to obtain a reliable structural model of this important transporter. In fact, a model of ABCA3 is still lacking and no crystallographic structures (of the transporter or of its orthologues) are available. With the adv...
Monoclonal antibodies specific for the dicarboxylate transporter of pea mitochondria were prepared and used to identify this substrate carrier. The hybridoma library was derived from mice that had been immunized with total mitochondrial membranes. The monoclonal antibodies specific for the dicarboxylate transporter were selected by screening hybridoma supernatants for their ability to inhibit m...
Background Comprehensive description of ketamine's molecular binding profile becomes increasingly pressing as use in real-life patient cohorts widens. Animal studies attribute a significant role in the substance's antidepressant effects to the serotonergic system. The serotonin transporter is a highly relevant target in this context, because it is central to depressive pathophysiology and treat...
The yields of cereal crops grown on acidic soils are often reduced by aluminum (Al) toxicity because the prevalence toxic Al3+ cations increases as pH falls below 5.0. Al-dependent release citrate from resistant lines maize is controlled ZmMATE1 which encodes a multidrug and compound extrusion (MATE) transporter protein. ZmMATE6 another member this family in whose expression also increased Al t...
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