In Colombia, pentavalent antimonials and miltefosine are the drugs of choice for the treatment of cutaneous leishmaniasis; however, their toxicity, treatment duration, (treatment adherence problems), cost, and decreased parasite sensitivity make the search for alternative treatments of American cutaneous leishmaniasis necessary. Based on the results found in a controlled, open, randomized, phas...

Introduction Currently, three types of therapy are approved for the treatment of exudative age-related macular degeneration (AMD): laser photocoagulation, photodynamic therapy with Verteporfin and intravitreal injections of antiangiogenic agents (Ranibizumab and Pegaptanib). Other treatments revealed to be ineffective or even more aggressive than natural disease progression. Examples of these l...

PURPOSE With the wide recognition of oncostatic effect of melatonin, the current study proposes a potential breast cancer target multimodality treatment based on melatonin-loaded magnetic nanocomposite particles (Melatonin-MNPs). METHODS Melatonin-MNPs were fabricated by the single emulsion solvent extraction/evaporation method. RESULTS Based on the facilitated transport of melatonin by the...

OBJECTIVES Different thermotherapeutic modalities such as transurethral microwave therapy or transurethral needle ablation have been developed to provide effective alternatives to surgical management of benign prostate hyperplasia (BPH). The mechanisms of thermotherapy, however, are not completely understood. We developed a model to investigate the effects of heat application on stromal cell vi...

We reported earlier the delivery of antiangiogenic single chain antibodies by using oncolytic vaccinia virus strains to enhance their therapeutic efficacy. Here, we provide evidence that gene-evoked production of melanin can be used as a therapeutic and diagnostic mediator, as exemplified by insertion of only one or two genes into the genome of an oncolytic vaccinia virus strain. We found that ...

The prevalence of cardiac malignant neoplasms in the general population has been shown to be significant higher than what was previously estimated, yet their treatment has remained difficult and effective therapies are lacking. In the current study, we developed a novel thermotherapy in which PEG-functionalized carbon nanotubes were injected into the tumor regions to assist in the targeted deli...

Medical applications of microwaves (i.e., a possibility to use microwave energy and/or microwave technique and technology for therapeutical purposes) are a quite new and very rapidly developing field. Microwave thermotherapy is being used in medicine for cancer treatment and treatment of some other diseases since early eighties. This paper is a contribution to a theory of phase array applicator...