aspirin is an anti-inflammatory drug, peroxyl radical scavenger, and antioxidant agent that inhibits phospholipases, nitric oxide synthetases, and cyclooxygenase enzymes. the existing literature contains no studies on the effects of various doses of aspirin on spinal cord injury (sci). therefore, we sought to investigate the putative effects of aspirin on experimental sci. the weight-drop injur...

objective: medical plants, as rich sources of natural antioxidants with antidiabetic effects, are used worldwide to diminish a variety of symptoms and many diseases. r. ribes l., which belongs to the family of polygonaceae, can provide symptomatic relief and assist in the prevention of the secondary complications of the diabetes. material and methods: 36 female adult rats were randomly divided ...

objective: atorvastatin has the pleiotropic effects, including anti-inflammation and antioxidant. therefore, this study considered to examine the effects of atorvastatin on nf-қb expression, as a main transcription factor for expression of inflammatory cytokines, in hyperglycemia-induced nephropathy in rat. materials and methods: twenty four male wistar rats were randomly divided into four grou...

objective: lamotrigine is an antiepileptic drug, widely used in the treatment of epilepsy; long-term use of this drug can cause hepatotoxicity. zingiber officinale roscoe (ginger) possesses antioxidant properties. in present research, the effect ofhydroalcoholic extract of ginger (heg) on the liver of lamotrigine-treated epileptic rats was investigated material and methods: forty-eight female w...

previous studies in humans and animals have reported that nicotine administration decreases body weightand caloric intake. opiate and cigarette have been used concomitantly as drug abuse. the aim of the present study was, therefore, to analyze the effect of chronic co-administration of nicotine and morphine on food intake, body weight and on some feeding-associated peptides. all experiments wer...

background: there is unprecedented increase in the processing and packaging of many plant materials into food supplements, herbal medicine, skincare and cosmetic products for human needs. baphia nitida is used for topical skincare products. toluene, a toxic aromatic solvent, is increasingly being used in the production of these skincare and cosmetic products in many industries. this study asses...

background: diabetes is a major public health problem. the development of new therapies that are able to improve glycemia management and even to cure diabetes is of great interest. in this study, protective effects of sodium tungstate against stz-induced beta-cell damages were investigated. methods: sixty rats were divided into six groups: control, diabetic, sodium tungstate treated diabetic ra...

previous studies have shown that the receptive field properties, spontaneous activity and spatio-temporal interactions of low-threshold mechanical somatosensory cells in the barrel cortex are influenced by c-fibers. in this study, we examined the effect of c-fiber depletion on response properties of barrel cortex neurons following experience dependent plasticity. methods: in this study, exterac...

Purpose: To explore the antidiabetic potential of Moringa oleifera leaf extract in type 2 diabetic rats, and underlying mechanisms.Methods: Streptozotocin (STZ) at a dose 40 mg/kg was given to high fat diet (HFD)- fed rats induce diabetes. M. doses 100, 200 400 were 3 groups rats. The area under curve (AUC) glucose homeostasis model assessment insulin resistance (HOMA-R) calculated using approp...

Objectives: This experimental study investigated the preventive effects of Celecoxib, a selective COX-2 inhibitor, on lung injury induced by intra-abdominal sepsis in rats. The assessed Celecoxib's potential to mitigate harmful impacts tissue. Methods: Thirty male Wistar albino rats, divided into three groups: normal control group, sepsis-induced group treated with saline, and Celecoxib. Sepsis...