OBJECTIVES Once weekly dosing of alendronate has been shown to provide equivalent efficacy to once daily dosing for treatment of osteoporosis in postmenopausal women. Whether patients will prefer weekly dosing to daily dosing for a chronic condition such as osteoporosis has not been studied. The aim of this international study was to assess preference for the weekly or daily dosing regimen of a...

I diopathic pulmonary fibrosis (IPF) is a challenging and frustrating disease for clinicians and patients confronted with this clinical entity, since it is associated with a dismal ,3-yr median survival from the time of diagnosis [1] and an effective treatment regimen is yet to be determined. The lack of an effective treatment option has encouraged investigation of new treatment regimens, and p...

OBJECTIVE To compare the incidence of toxicity of 8 different chemotherapy regimens, including doxorubicin + paclitaxel, doxorubicin, capecitabine, CMF (cyclophosphamide + methotrexate + 5-fluorouracil), FAC (fluorouracil + doxorubicin + cyclophosphamide), doxorubicin + docetaxel, doxorubicin + cyclophosphamide and paclitaxel in the treatment of metastatic/advanced breast cancer. RESULTS This...

Introduction / objectives Changing an antimicrobial treatment regimen has shown to influence the occurrence of antimicrobial resistance, with regimen consisting of the dose, the treatment interval, the duration of therapy, and the route of administration of the drug. For concentration dependent antimicrobials there is substantial evidence to encourage the use of a high dose, with regular treatm...

Background Treatment options among Human Immunodeficiency Virus (HIV)-infected children are limited as only a few Highly Active Antiretroviral Therapy (HAART) are approved worldwide for paediatric use. Among children, frequent changes in HAART regimen can rapidly exhaust treatment options, and information addressing this issue is scarce. Objective The aim of the study was to determine factors...

© 2014 Lippincott Williams & Wilkins www.pidj.com | 993 In Reply: Short Intensified Treatment in Children With Drug-Susceptible Tuberculous Meningitis child effectively on isoniazid monotherapy for most of their treatment. This can be a problem in areas with high prevalence of isoniazid resistance. In addition, the poor CSF penetration of ethambutol renders its inclusion in the regimen question...

Background: The effect of corticosteroid therapy on corneal wound healing is controversial. The objective of this study was to evaluate the effects of combination therapy with dexametha-sone and acetylcysteine at different times and durations on experimentally-induced corneal wounds and haze in rabbits. Methods: Eighteen adult New Zealand white rabbits were divided into three groups of ...

pleuropulmonary blastoma (ppb) is a rare, malignant intrathoracic tumor that occurs mostly in children before 5 years old. it consists about 15% of all primary pediatric pulmonary tumors and shows various mesenchymal components. its presentations are nonspecific and common symptoms include fever, cough, chest pain, respiratory distress, and pulmonary infection. ppb should be considered in the d...

OBJECTIVE To describe the rates of cure, treatment failure, and treatment abandonment obtained with the basic regimen recommended by the Brazilian National Ministry of Health (rifampin, isoniazid, pyrazinamide, and ethambutol for two months, followed by isoniazid and rifampin for four months) involving the use of fixed-dose combination tablets (self-administered treatment), as well as to descri...