نتایج جستجو برای: triolein
تعداد نتایج: 525 فیلتر نتایج به سال:
Abstract Response surface methodology (RSM) was used to optimize the degree of esterification p -coumaric acid triolein via lipase-catalyzed acidolysis, and enzyme load, reaction time mole ratio substrates were selected as variables in experimental design. The results showed that model employed highly sufficient for determining effectiveness interaction three variables, substrates, on dependent...
Tetrahydrolipstatin inhibits pancreatic lipase from several species, including man, with comparable potency. The lipase is progressively inactivated through the formation of a long-lived covalent intermediate, probably with a 1:1 stoichiometry. The lipase substrate triolein and also a boronic acid derivative, which is presumed to be a transition-state-form inhibitor, retard the rate of inactiva...
Tetrahydrolipstatin (orlistat) (S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]methyl]dodecyl N-formyl-L-leucinate, a potent inhibitor of pancreatic lipase, is hydrophobic, amphipathic, and water-insoluble. It binds irreversibly to pancreatic lipases and inhibits fat absorption. The focus of this investigation is on the distribution of orlistat in emulsified fat and vesicular membranes such as might be...
The effect of a whole pancreas preparation (Viokase) has been investigated in 11 patients with pancreatic steatorrhoea and in five patients with steatorrhoea due to other causes. The appearance of the stool, faecal fat, and stool and blood radioactivity after a given dose of I(131) triolein (Raolein) were employed in assessing the response to Viokase therapy. Pancreatic steatorrhoea was conside...
The [14C]-triolein absorption test has been assessed using a preprepared fat meal in a procedure that can be completed within a working day on an inpatient or outpatient basis. An initial study showed complete discrimination between 30 control subjects and 13 patients with raised faecal fat excretion. A prospective evaluation in 57 patients under investigation for gastrointestinal disease showe...
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