Hyoscyamus albus is a well-known source of the tropane alkaloids, hyoscyamine and scopolamine, which are biosynthesized in the roots. To assess the major biochemical adaptations that occur in the roots of this plant in response to iron deficiency, we used a small-scale proteomic approach in which 100 mg of root tips were treated with and without Fe, respectively, for 5 days. Two-dimensional min...

Anisodus tanguticus (Maxim.) Pascher, a medicinal plant growing in the Tibetan Plateau region with various values, is mainly used for extraction of tropane alkaloids (TAs), and increased demand A. has triggered its overexploitation. The cultivation this necessary quality control conservation wild resources. During 2020 2021, split-plot experiment three replicates was to study different planting...

The title compound, C(17)H(24)NO(5)S(+)·C(18)H(13)O(8) (-), is the key inter-mediate during the preparation of lesatropane [systematic name (1R,3S,5R,6S)-6-acetoxy-3-(4-methylphenylsulfonyloxy)tropane], a potential anti-glaucoma agent. The tertiary N atom of the tropane ring is involved in inter-molecular N-H⋯O hydrogen bonding, and the carboxylate groups are involved in inter-molecular O-H⋯O h...

This study was aimed to determine the effects of different concentrations L-phenylalanine (0.25, 0.50 and 1.00 mM L-Phe) applied adventitious root cultures for culture durations on growth production tropane alkaloids phenolics in Hyoscyamus niger. For this purpose, roots obtained from petiole explants vitro seedlings were used as plant materials. After cultured liquid Murashige Skoog (MS) mediu...

Datura metel is an annual or perennial herbaceous plant, belonging to the family Solanaceae with major bioactive components such as tropane alkaloids. Several animals were reported have manifested toxicity signs including circulatory and respiratory failure, resulting in death after consumption of plant. The present study sought unravel haematological effects D. leaves well its ameliorative pot...

Stachydrine (I), the methyl betaine of proline, occurs in a number of plants (1). Its biogenesis has been the subject of an investigation by Klein and Linser (2) who found an increase in stachydrine content of the planbs after an injection of proline into the hollow stems of Guleopsis ochroleuca and Stachys palustris. They suggest two schemes for the biogenesis of proline, one from ornithine, t...

The alpha7 nicotinic acetylcholine receptor (nAChR)-selective partial agonist tropisetron is a conjugate of an indole and a tropane group. We tested compounds structurally related to either the indole or tropane domains of tropisetron on oocytes expressing human alpha7. alpha4beta2, or alpha3beta4 nAChR or rat 5HT(3A) receptors. The simple compounds tropane and tropinone had alpha7-selective ag...