It is over 100 years since Felix Marchand identified choriocarcinoma as a tumor arising from placental villous trophoblast. In 1956, Hertz etal 1 first reported the cure of a patient with metastatic choriocarcinoma using chemotherapy. The next decade saw Hertz and colleagues at the National Institute of Health, Brewer in Chicago and Bagshawe in London develop the chemotherapeutic approach to ge...

Spindle cell neoplasms are defined as neoplasms that consist of spindle-shaped cells in the histopathology. Spindle cell neoplasms can affect the oral cavity. In the oral cavity, the origin of the spindle cell neoplasms may be traced to epithelial, mesenchymal and odontogenic components. This article aims to review the spindle cell neoplasms of the oral cavity with emphasis on histopathology. ...

BACKGROUND The aim of the study was to record the incidence of treatment for infertility prior to development of gestational trophoblastic disease (GTD). METHODS AND RESULTS A retrospective analysis was undertaken of 231 consecutive women receiving chemotherapy for persistent GTD at Weston Park Hospital, Sheffield, from 1991 to 2001. Three patients in this group had received treatment for inf...

PURPOSE To compare two single-agent chemotherapy (ChT) regimens evaluating, in first-line treatment, response and side effects and, in final single-agent treatment, the outcomes, among Brazilian patients with low-risk gestational trophoblastic neoplasia (GTN), according to International Federation of Gynecology and Obstetrics (FIGO) 2002. METHODS Retrospective analysis of two concurrent cohor...

OBJECTIVE To assess the need for pulmonary surgery in the treatment of refractory gestational trophoblastic neoplasia with lung metastasis after normalization of serum beta human chorionic gonadotropin (β-hCG) level with salvage chemotherapy. MATERIALS AND METHODS A review of medical records of patients with refractory gestational trophoblastic neoplasia who underwent pulmonary surgery and re...

a Department of Obstetrics and Gynecology, University of Hong Kong, Queen Mary Hospital, Hong Kong, China b Department of Gynecology and Obstetrics, Yale University School of Medicine, New Haven, CT, USA c Department of Obstetrics and Gynecology, USA hCG Reference Service and Dagger Department of Biochemistry and Molecular Biology, University of New Mexico Health Science Center, Albuquerque, NM...

SUMMARY A human hormone-synthesizing trophoblastic cell system has been established in vitro and may prove to be the first func tional human embryonic cell line in continuous culture. Cho-rionic gonadotropin hormone produced by these cultures serve as a marker for identification of the trophoblastic cell. No interruption in this property nor change in cytologie display has occurred during 1.5 y...

References 1 UK Medical Eligibility Criteria for Contraceptive Use (UKMEC 2009). 2009. http://www.fsrh.org/admin/ uploads/UKMEC2009.pdf [Accessed 10 February 2010]. 2 UK Medical Eligibility Criteria for Contraceptive Use (UKMEC 2005/2006). 2006. http://www.fsrh.org/ admin /up loads /a rch ive /UKMEC2005_06.pd f [Accessed 10 February 2010]. 3 Gaffield ME, Kapp N, Curtis KM. COC and IUD use among...