Niosomes as a novel drug delivery system is nonionic surfactant-based vesicle, have attracted much attention in pharmaceutical fields due to their excellent behavior encapsulating both hydrophilic and hydrophobic agents. In the present study comparative free radical scavenging anti-proliferative potential of ethyl acetate root extract Aconitum heterophyllum (EAEAH) roots loaded phyto-niosomes (...

Yeast cells are protected by a cell wall that plays an important role in the exchange of substances with the environment. The cell wall structure is dynamic and can adapt to different physiological states or environmental conditions. For the investigation of morphological changes, selective staining with fluorescent dyes is a valuable tool. Furthermore, cell wall staining is used to facilitate ...

Abstract Introduction Glutaminolysis, beside glycolysis, is a key metabolic pathway of cancer cell that provides energy and substrates for the synthesis nucleic acids, proteins, lipids. The mediated by both mitochondrial cytosolic enzymes. Neither expression glutaminolysis enzymes in colon cells nor influence various oxygen concentrations on their has been studied so far. Objectives aim study w...

Objective: The natural compound, thymoquinone (TQ) has demonstrated potential anticancer properties in inhibiting cell proliferation and promoting apoptosis myeloid leukemia cells, breast cancer others. However, the effect mechanism of TQ on AML cells still not fully understood. In this study, authors examined effects expression JAK/STAT-negative regulator genes SOCS-1, SOCS-3, SHP-1, their con...

The present study was intended to standardize the protocol for the synthesis of silver nanoparticles (AgNPs) using aqueous extract of Dictyota bartayresiana J.V. Lamouroux and evaluate cytotoxic potentials using brine shrimp bio-assay activity and trypan blue dye exclusion method. The reduction of pure Ag+ ions was monitored by measuring the UV-Vis spectrum of the solution at 200-900 nm and the...

The toxicity of amphotericin B (AmB) for neutrophils and the protective effect of serum cholesterol were investigated. Neutrophils were exposed in vitro to varying concentrations of AmB. As judged by trypan blue exclusion, neutrophil viability decreased by 40% (P < 0.001) within 30 min of incubation in sterol-free buffer containing 5 mug of AmB per ml. In the presence of 4 mg of cholesterol per...

BACKGROUND Sirolimus is recently reported to have antitumour effects on a large variety of cancers. The present study was performed to investigate sirolimus's ability to inhibit growth in T24 bladder cancer cells. METHODS T24 bladder cancer cells were treated with various concentrations of sirolimus. MTT assay was used to evaluate the proliferation inhibitory effect on T24 cell line. The viab...