We use a flux transport model to simulate the evolution of the Sun’s total and open magnetic flux over the last 26 solar cycles (1713–1996). Polar field reversals are maintained by varying the meridional flow speed between 11 and 20 m s , with the poleward-directed surface flow being slower during low-amplitude cycles. If the strengths of the active regions are fixed but their numbers are taken...

Water quality is an important factor to consider when attempting to reconcile mathematical optimisation modellingwith the physical reality of water-resource systems. In particular, when the greater part of water resources in supply systems comes from artificial reservoirs, as in Mediterranean regions, a simplified approach based on the attribution of the trophic state of reservoirs can be devel...

Efflux transporters expressed in the apical membrane of intestinal enterocytes have been implicated in drug oral absorption. The current study presents a strategy and tools to quantitatively predict the impact of efflux on oral absorption for new chemical entities (NCEs) in early drug discovery. Sixty-three marketed drugs with human absorption data were evaluated in the Caco-2 bidirectional per...

The analytical performance and the clinical utility of a thyrotropin receptor (TSHR)-stimulating immunoglobulin (TSI) bioassay were compared with those of a TSHR-binding inhibitory immunoglobulin (TBII) assay. Limits of detection (LoD) and quantitation (LoQ), assay cutoff, and the half-maximal effective concentration (EC(50)) were measured. Dilution analysis was performed in sera of hyperthyroi...

OBJECTIVE To report a case of vaccine-induced Graves' disease successfully managed with L-carnitine and propranolol and without antithyroid drugs (ATDs). ATDs sometimes need to be used at low doses or can be contraindicated/refused. One of the ancillary compounds available is L-carnitine. L-carnitine is a naturally occurring quaternary amine, which acts by impairing thyroid hormone access to th...

We studied whether common polymorphisms in genes involved in folate metabolism affect methotrexate (MTX) sensitivity. Ex vivo MTX sensitivity of lymphoblasts obtained from pediatric patients with acute lymphoblastic leukemia (ALL; n = 157) was determined by the in situ thymidylate synthase inhibition assay after either continuous (21 hours; TSI(50, cont)) or short-term (3 hours; TSI(50, short))...

BACKGROUND Established methods to determine asynchrony suffer from high intra- and interobserver variability and failed to improve patient selection for cardiac resynchronization therapy (CRT). Thus, there is a need for easy and robust approaches to reliably assess cardiac asynchrony. METHODS AND RESULTS We performed echocardiography in 100 healthy subjects and 33 patients with left bundle br...

The purpose of this research is to adapt the Teaching Style for Successful Intelligence Questionnaire (TSI-Q) developed by Paloş and Maricutoui (2006) Turkish. was carried out on three separate groups consisting 305 high school teachers. In linguistic equivalence study, it obtained that there were strong, positive, significant correlations between responses participants English Turkish forms sc...

The current study deals with the physicochemical characterization, temporal variability and trophic state evaluation of a post glacial mountain lake in eastern Himalaya during the period of 2014-2016. Notable seasonal variations are recorded for physicochemical parameters of lake water. The values for electrical conductivity, total suspended solids, total dissolved solids, total alkalinity and ...

Purpose It is still equivocal whether oxygen uptake recovery kinetics are limited by oxygen delivery and can be improved by supplementary oxygen. The present study aimed to investigate whether measurements of muscle and pulmonary oxygen uptake kinetics can be used to assess oxygen delivery limitations in healthy subjects. Methods Sixteen healthy young adults performed three sub-maximal exerci...