Background: Tuberculosis of the genital tract is one of the major causes of gynecological morbidity. Genital TB affects about 12% of patients with pulmonary tuberculosis and represents 15-20% of extrapulmonary tuberculosis. Genital TB may be asymptomatic but involves genital organs such as fallopian tubes, endometrium, ovaries, cervix, vulva/ vagina and myometrium. The major presenting symptom ...

background: predicting the incidence of tuberculosis (tb) plays an important role in planning health control strategies for the future, developing intervention programs and allocating resources. objectives: the present longitudinal study estimated the incidence of tuberculosis in 2014 using box-jenkins methods. materials and methods: monthly data of tuberculosis cases recorded in the surveillan...

Background: One of the fundamental issues of infectious disease treatment is drug resistance. The aim of the present study was to investigate the first-line anti-tuberculosis drug resistance rates and determine the risk factors related to multidrug resistant mycobacterium tuberculosis.Methods: From March 2011 to September 2012, mycobacterial strains were collected from one hundred fifteen diagn...

conclusions serum ada activity with high specificity percentage may be a useful alternative test in restricted resource areas to rule out diagnosis of ptb. however, serum ada activity is not a useful tool for tb diagnosis. mean serum ada level in the ptb group was clearly higher than the mean serum ada in the other three groups. mean serum ada was 26 iu/l in ptb patients, 19.48 iu/l in patients...

Tuberculosis (TB) is a major global health problem and often coincides with nutritional deficiency. In fact, vitamin D deficiency has been reported among TB patients, and vitamin D receptor polymorphisms are associated with susceptibility to Mycobacterium tuberculosis. High doses of vitamin D were widely used to treat TB patients in the preantibiotic era. This approach was successful: vitamin D...

Dear Editor, Tuberculosis (TB) is responsible for a large portion of morbidity and mortality worldwide. According to WHO report, tuberculosis is responsible for at least 2 million deaths per year, so 90% of these occurring in developing countries. 1,2 Recently, it has been shown that multidrug-resistance (MDR) and extensively drug-resistant tuberculosis (XDR-TB) are the most important factors c...

We aimed to determine whether shotgun proteomic approaches could be used to identify tuberculosis (TB)-specific biomarkers in the urine of well-characterised patients with active TB versus no TB. Patients with suspected TB (n=63) were classified as: definite TB (Mycobacterium tuberculosis positive culture, n=21); presumed latent-TB infection (LTBI) (M. tuberculosis negative culture, no radiolog...

Background: Microscopic smear examination is the most common test in tuberculosis (TB) detection. It is, however, not strong enough to identify TB in the majority of afflicted individuals; thus, a significant number of TB patients are smear negative and capable of transmitting the infection. The aim of this study was to evaluate the rate of smear-negative TB in northwest Iran.Methods: In this c...

A promising test to distinguish between active tuberculosis and latent tuberculosis As pointed out by the authors of the case report, the distinction between active tuberculosis (TB) and latent tuberculosis is impossible with the blood tests in conventional use. 1 Nevertheless what seems to show great promise is the use of host RNA expression profiles to distinguish between active and latent tu...

The goals of the present study were twofold: (i) to compare the repertoires of antigens in culture filtrates of in vitro-grown Mycobacterium tuberculosis that are recognized by antibodies from noncavitary and cavitary tuberculosis (TB) patients and (ii) to determine the extent of variation that exists between the antigen profiles recognized by individual TB patients. Lipoarabinomannan-free cult...