Banyatsuppasin et al. suggested the role of the spleen in controlling mononuclear phagocytic activity in E/b-Thal patients [6]. TNF-α play roles as an inducer and effector of monocyte activation [6]. Additionally, TNF-α returned to normal after 12, 6, and 3 months of deferiprone treatment [7]. Therefore, chelation treatment can affect apoptosis independently of splenectomy. It might be importan...

OBJECTIVE Ultra-small superparamagnetic iron oxide nanoparticles (USPIO) are promising contrast agents for magnetic resonance imaging (MRI). USPIO mediated proton relaxation rate enhancement is strongly dependent on compartmentalization of the agent and can vary depending on their intracellular or extracellular location in the tumor microenvironment. We compared the T1- and T2-enhancement patte...

OBJECTIVE Two main forms of cell death are encountered in biology: apoptosis (i.e., programmed cell death) and necrosis (i.e., accidental cell death). Because necrosis and apoptosis can lead to cell removal, one might intuit that they are both desirable in cancer treatment. However, in the setting of glioblastoma multiforme, a malignant brain tumor for which the presence of necrosis is an impor...

Interleukin-33 (IL-33)/IL-33 receptor (IL-33R, ST2) signaling pathway promotes mammary cancer growth and metastasis by inhibiting anti-tumor immunity. However, the role of IL-33/IL-33R axis in neoangiogenesis and tumor necrosis is not elucidated. Therefore, the aim of this study was to investigate the role of IL-33/IL-33R axis in mammary tumor necrosis. Deletion of IL-33R (ST2) gene in BALB/c m...

Newcastle disease virus (NDV) is promising antitumor agent that triggers immediate cytolysis of the tumor, apoptosis and activation immune system. This study was aimed at testing antiangiogenic NDV Performance on a model breast cancer. has been studied against mammalian adenocarcinoma AN3 transplanted into syngeneic immunocompetent mice through intratumoral injection to determine activity in vi...

AIMS Tumor necrosis is associated with aggressive features of endometrial cancer and poor prognosis. Here, we investigated gene expression patterns and potential treatment targets related to presence of tumor necrosis in primary endometrial cancer lesions. METHODS AND RESULTS By DNA microarray analysis, expression of genes related to tumor necrosis reflected multiple tumor-microenvironment in...

Background: Invasive breast cancer (IBC) has long been thought as non-immunogenic, but in recent decades it reported that tumour micro-environment (TME) encompasses tumor-infiltrating lymphocytes (TILs), which help creating anti-tumor immune response. On the other hand, tumor buddings (TB) from invasive front of contribute to invasion and metastasis. We aim evaluate TILs TB IBC correlate them w...