Teng, Xingwu, Hanfang Zhang, Connie Snead, and John D. Catravas. Molecular mechanisms of iNOS induction by IL-1b and IFN-g in rat aortic smooth muscle cells. Am J Physiol Cell Physiol 282: C144–C152, 2002;—In rat aortic smooth muscle cells (RASMC), interferon (IFN)-g enhanced nitrite accumulation and type II nitric oxide synthase (iNOS) protein expression induced by interleukin (IL)-1b. IFN-g a...

Interleukin-1b (IL-1b), a polypeptide immune mediator, is induced within the central nervous system in response to a variety of pathological stimuli, including systemic infection, hypoxia, brain trauma, and seizure. IL-1b action on the g-aminobutyric acid type A (GABAA) inhibitory neurotransmitter receptor was investigated in whole cell patch-clamped cultured hippocampal neurons. Application of...

Assays that detect antibody to hepatitis C virus (HCV) are used to screen blood donors and patients with hepatitis. Current enzyme-linked immunosorbent assay (ELISA)-based methods are invariably based upon antigens from expressed recombinant proteins or oligopeptides from HCV type 1. Some HCV antigens used in screening assays are coded by regions of the HCV genome that show extensive variabilit...

Pseudohypoparathyroidism (PHP) is a metabolic disorder characterized by organ resistance to the action of parathyroid hormone. PHP type 1 is subclassified into two apparent disorders, type 1a (PHP1a) and type 1b (PHP1b). Patients with PHP1a show Albright hereditary osteodystrophy including short stature. Patients with PHP1b have no such skeletal defects, however, literature regarding the growth...

Previous work has shown that bisperoxo(1,10-phenanthroline)-oxovanadate(v) anion [bpV(phen)] induces potent insulin-mimicking effects in the rat, selectively activates the endosomal (EN) insulin receptor kinase (IRK) in liver, and markedly abolishes endosomal IRK-associated phosphotyrosine phosphatase (PTP) activity while reducing that of total ENs by approximately 30%. In this study we examine...

Abstract Purpose The therapeutic use of oral hypoglycaemic agents in the management type-2 diabetes mellitus (T2DM) is without adverse effects; thus, calls for alternative and novel candidates from natural products medicinal plants. Method study explored molecular docking dynamics (MD) simulation approaches to identify key antidiabetic metabolites Crescentia cujete . Results Molecular results i...

human interferons (ifns) are key cytokines secreted by immune system. they have several effects such as antiviral and anti tumors activity, activating immune cells and healing of multiple sclerosis. the type ifns present in humans are α, β and υ. ifn β is a polypeptide, normally produced by fibroblasts and seems to be more species-specific than ifn . structural properties of i fns are importan...