The objective of this study was to test the hypothesis that renal interstitial (RI) cGMP is natriuretic in vivo. In conscious rats (n=8), urinary sodium excretion (U(Na)V) was significantly greater on days 3 and 4 of RI infusion of cGMP (1.17+/-0.14 and 1.61+/-0.11 mmol/24 h, respectively) than during vehicle infusion (0.56+/-0.15 and 0.70+/-0.17 mmol/24 h, respectively) (P<0.01). Similarly, U(...

al monogamy4 and covert sex outside the main relationship. Delayed marriage and high divorce rates mean that growing numbers of individuals experience multiple sexual partners in a lifetime, and this greatly increases their exposure to infection. Furthermore, National Health and Social Life Survey data show that around 25% of men and 10% of women report extramarital or extracohabitational affai...

Rodent animal models have been widely used for studying neurologic and toxicological events associated with cocaine abuse. It is known that the mouse is more susceptible to cocaine-induced hepatotoxicity (CIH) than the rat. However, the causes behind this species-dependent sensitivity to cocaine have not been elucidated. In this study, cocaine metabolism in the mouse and rat was characterized t...

Naja naja karachiensis envenomation was found to hit more drastically heart, liver, and kidneys. 400 μg/kg of venom-raised moderate serum levels of ALT (72 ± 4.70 U/L, 0.1 > P > 0.05), AST (157 ± 24.24 U/L, 0.1 > P > 0.05), urea (42 ± 3.08 mg/dL, 0.05 > P > 0.02), creatinine (1.74 ± 0.03 mg/dL, 0.01 > P > 0.001), CK-MB (21 ± 1.5 U/L, 0.05 > P > 0.02), and LDH (2064 ± 15.98 U/L, P < 0.001) were ...

Nanotechnology, through nanomedicine, allowed drugs to be manipulated into nanoscale sizes for delivery to the different parts of the body, at the same time, retaining the valuable pharmacological properties of the drugs. However, efficient drug delivery and excellent release potential of these delivery systems may be hindered by possible untoward side effects. In this study, the sub-acute toxi...

Traditional supplemental dietary phytase loses activity during steam pelleting. The thermal tolerance and bioefficacy of a phytase product with a thermoprotective coating [coated phytase (C-phytase)] was compared in mash and pelleted diets to a traditional, uncoated phytase (U-phytase) added to a negative control (NC) diet, formulated with reduced dietary Ca and P, and compared with a corn-soyb...

Let KG be the group ring of a group G over a commutative ring K with unity. The rings KG are described for which xxσ = xσx for all x = ∑ g∈G αgg ∈ KG, where x → xσ = ∑ g∈G αgf(g)σ(g) is an involution of KG; here f : G → U(K) is a homomorphism and σ is an antiautomorphism of order two of G. Let R be a ring with unity. We denote by U(R) the group of units of R. A (bijective) map : R → R is called...

Background & Aims Little is known about the relationship between ustekinumab exposure during first 2 weeks of treatment and outcomes patients with Crohn’s disease (CD). We investigated serum concentrations endoscopic biochemical remission in CD. Methods In a prospective observational study, we measured samples from 41 consecutive who started (approximately 6 mg/kg, intravenously, then 90 mg eve...

The purpose of this study was to determine the effectiveness of the systemic administration of high dose erythropoietin (EPO) in a 6‑hydroxydopamine (6‑OHDA)‑ induced rat model. Rats were divided into 7 groups. Groups 1‑4 were administered daily EPO doses of 0; 2,500; 5,000 and 10,000 U/kg via intraperitoneal injection (i.p.) for 5 days. The EPO concentration in cerebrospinal fluid (CSF) was de...