Allogeneic stem cell transplantation with umbilical cord blood (UCB) cells is limited by the cell dose a single unit provides recipients. Ex vivo expansion is one strategy to increase the number of cells available for transplantation. Aastrom Biosciences developed an automated continuous perfusion culture device for expansion of hematopoietic stem cells (HSCs). Cells are expanded in media suppl...

The simultaneous expansion and harvest of hematopoietic stem cells and mesenchymal stem cells derived from umbilical cord blood were carried out using bioreactors. The co-culture of umbilical cord blood (UCB)-derived hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) was performed within spinner flasks and a rotating wall vessel (RWV) bioreactor using glass-coated styrene copolym...

The aim of the present study was to investigate the prognostic significance of the expression of transcription factors, c-Fos, c-Jun and transmembrane protein CD147, in urothelial carcinoma of the bladder (UCB). The current study investigated the clinical significance of these factors in the development, progression and survival analysis of UCB. Immunohistochemistry was employed to analyze c‑Fo...

We present an extensive study of the key problem of online learning where algorithms are allowed to abstain from making predictions. In the adversarial setting, we show how existing online algorithms and guarantees can be adapted to this problem. In the stochastic setting, we first point out a bias problem that limits the straightforward extension of algorithms such as UCB-N to time-varying fee...

In the present study, we analyzed the immunological characteristics of mononuclear cells (MNC) isolated from both neonatal umbilical cord blood (UCB) and maternal peripheral blood (MPB) during the delivery. The in vitro proliferative response of UCB T lymphocytes was significantly reduced compared to the maternal response to phytohemagglutinin A, pokeweed mitogen, and alloantigen stimulation, i...

Transcription factors play a central role in the epithelial-mesenchymal transition (EMT), which is one of the biomolecular mechanisms involved in the progression of urothelial carcinomas of the bladder (UCB). In this study, we analyzed the immunoexpression of Twist 1, Snail, Slug and β-catenin in relation to histopathological prognostic parameters of UCB. The obtained results indicated the asso...

ABSTRACT. In the stochastic multi-armed bandit problem we consider a modification of the UCB algorithm of Auer et al. [4]. For this modified algorithm we give an improved bound on the regret with respect to the optimal reward. While for the original UCB algorithm the regret in Karmed bandits after T trials is bounded by const · K log(T ) , where measures the distance between a suboptimal arm an...

Since the success of the first umbilical cord blood (UCB) transplantation in a child with Fanconi anaemia in 1989, great interests have emerged for this source of stem cells. UCB provides an unlimited source of ethnically diverse stem cells and is an alternative for bone marrow (BM) and peripheral blood (PB) haematopoietic stem cell transplantation (HSCT). Thus, UCB and manipulated stem cells a...

We describe the main technical difficulties in the proof for TS algorithm as compared to the UCB algorithm. In UCB algorithm, the suboptimal arm 2 will be played at time t, if its UCB value is higher, i.e. if UCB2,t−1 > UCB1,t−1. If we have pulled arm 2 for some amount of times Ω( log(T ) ∆2 ), then with a high probability this will not happen. This is because after n2,t ≥ Ω(log(T )/∆), using c...