Contrast-enhanced imaging has grown significantly in the past two decades. Technology evolved from based on linear principles to elaborate pulsing and microbubble-specific detection strategies. This review provides a broad overview of research published these topics, emphasizing progress made, current challenges, future considerations. We cover physical conceptual underpinnings ultrasound contr...

INTRODUCTION Gas-filled microbubbles were originally developed as an intravascular contrast agent to enhance backscattering in ultrasound imaging. Microbubbles possess the ability to be an MR susceptibility contrast agent due to the induction of large local magnetic susceptibility differences by the gas-liquid interface. Feasibility of microbubbles as an MR pressure sensor, based on the suscept...

Ultrasound-mediated microbubbles destruction has been proposed as an innovative method for noninvasive delivering of drugs and genes to different tissues. Microbubbles are used to carry a drug or gene until a specific area of interest is reached, and then ultrasound is used to burst the microbubbles, causing site-specific delivery of the bioactive materials. Furthermore, the ability of albumin-...

Measurements were undertaken to determine the unknown microbubble-size distribution of a dodecafluoropentane (DDFP) emulsion consisting of 10 droplets/ml in surfactant-stabilized water. The acoustic backscatter of 2-microsecond-duration tonebursts of 30-MHz focused ultrasound was measured from the emulsion as it moved in a coaxial flow. Calibration for the system was accomplished using 3-mm-rad...