Introduction Understanding how mechanical loading affects cartilage is vital for understanding how osteoarthritis develops and how tissue engineered cartilage-scaffold constructs behave under conditions simulating in vivo cyclic loading. We have developed an in vitro dynamic loading chamber. In this report, development of chondrocyte apoptosis in unloaded and loaded bovine cartilage under these...

Abstract A high-speed railway has high requirements for line smoothness, and uneven settlement control is the primary factor considered in design operation of subgrade. The emergence lightweight subgrade structures meets needs development railway. As a kind filling material with good performance, foam concrete can effectively reduce load excessive cost foundation treatment. This paper studied d...

OBJECTIVES/HYPOTHESIS The mechanical properties of normal auricular cartilage provide a benchmark against which to characterize changes in auricular structure/function due to genetic defects creating phenotypic abnormalities in collagen subtypes. Such properties also provide inputs/targets for auricular reconstruction scaffold design. Several studies report the biomechanical properties for sept...

The modulus of elasticity represents the soil stiffness; it was used to design and analyze foundation, slope stability, retaining structure, etc. It is one main input parameters in finite element method for analyzing behavior. scope this study evaluate correlation between (E) cohesion (c u ) remolded undisturbed samples clayey so can assess effect lateral confining pressure on elasticity. uncon...

We describe a modeling methodology intended as a preliminary step in the identification of appropriate constitutive frameworks for the time-dependent response of biological tissues. The modeling approach comprises a customizable rheological network of viscous and elastic elements governed by user-defined 1D constitutive relationships. The model parameters are identified by iterative nonlinear o...

In this work, a systematic study of the viscoelastic properties of hydrogels based on polyethylene glycol diacrylate (PEG-DA) is presented. In addition to artificial PEG-DA-based hydrogels, natural hydrogels in the form of human articular cartilage were examined. Specimens were (unconfined) compression tested under static and dynamic load. Besides this, instrumented indentation tests with diffe...

The elastic strain energy potential for nonlinear fibre-reinforced materials is customarily obtained by superposition of the potentials of the matrix and of each family of fibres. Composites with statistically oriented fibres, such as biological tissues, can be seen as being reinforced by a continuous infinity of fibre families, the orientation of which can be represented by means of a probabil...

The triphasic constitutive law [Lai, Hou and Mow (1991)] has been shown in some special 1D cases to successfully model the deformational and transport behaviors of charged-hydrated, porous-permeable, soft biological tissues, as typified by articular cartilage. Due to nonlinearities and other mathematical complexities of these equations, few problems for the deformation of such materials have ev...

Meniscal repair is widely used as a treatment for meniscus injury. However, where meniscal damage has progressed such that repair is not possible, approaches for partial meniscus replacement are now being developed which have the potential to restore the functional role of the meniscus, in stabilising the knee joint, absorbing and distributing stress during loading, and prevent early degenerati...

Class F fly ash cannot be used alone in soil stabilization applications as it is not selfcementing. An activator such as Portland cement or lime must be added to produce cementitious products often called pozzolan stabilized mixtures. The developed mixture must possess adequate strength and durability, should be easily compacted, and most importantly should be economical and environmentally fri...