Introduction: The effects of cannabinoids (CBs) on synaptic plasticity of hippocampal dentate gyrus neurons have been shown in numerous studies. However, the effect of repeated exposure to cannabinoids on hippocampal function is not fully understood. In this study, using field potential recording, we investigated the effect of repeated administration of the nonselective CB receptor agonist WIN5...

micropolar plasticity provides the capability to carry out post-failure simulations of geo-structures due to microstructural considerations and embedded length scale in its formulation. an essential part of the numerical implementation of a micropolar plasticity model is the integration of the rate constitutive equations. efficiency and robustness of the implementation hinge on the type of inte...

Classical computing has well-established formalisms forspecifying, refining, composing, proving, and otherwise reasoningabout computations. These formalisms have matured over the past70 years or so.Unconventional Computing includes the use novel kinds of sub-strates – from black holes and quantum effects, through to chem-icals, biomolecules, even slime moulds – to perfor...

GRASP proteins associate with the Golgi apparatus and have been implicated in the stacking of Golgi cisternae, vesicle tethering, and mitotic progression, but their specific functions are unclear. In this issue, Kinseth et al. (2007) show unexpectedly that a GRASP homolog is required for an unconventional secretory pathway that bypasses the usual route for Golgi-dependent membrane traffic.

Computer music is a truly interdisciplinary field; practitioners are well known for experimenting with new and developing technologies from a wide span of disciplines. Such experimentation is a tradition that stems back to the genesis of computer music, where a mathematician with a musical background programmed an early computer in the early 1950s to play a tune. The area of computer music has ...

An evolving computation is one whose characteristics vary during its execution. These variations have many di erent origins and can manifest themselves in several ways. Thus, for example, the parameters of a computation, such as the data it uses, may vary with time independently of the computational environment in which the computation is carried out. Alternatively, it may be that the data inte...