Since half of the genes are inherited from paternal side, maternal immune system has to tolerate presence foreign antigens. Regulatory T cells facilitate development and maintenance peripheral tissue tolerance fetus during pregnancy. Reduction in regulatory is associated with complications pregnancy, including spontaneous abortion. Recent studies mouse models have shown that adoptive transfer T...

Genetic factors in the form of maternal or fetal single gene disorders, chromosomal abnormalities, inherited thrombophilia and other genes involved are the main causes of recurrent abortion (RA). The risk of miscarriage is highest among couples where the woman is >35 years of age and the man >40 years of age. In about 50–70% of miscarriage, a chromosome abnormality is identified in the products...

BACKGROUND Etiology of more than half of Recurrent Spontaneous Abortion. The etiology of more than 50 percent of Recurrent Spontaneous Abortions (RSA) cases has been remained unexplained. It is supposed that RSA may have "paternal effect" due to supply 50% of embryonic genomic content by male gamete. OBJECTIVE The aim of present study was to evaluate the role of sperm apoptosis and protamine ...

Low maternal folate or vitamin B12 status has been implicated in numerous pregnancy complications including spontaneous abortion. The primary aim of this study was to test a polymorphism within the trifunctional folate enzyme MTHFD1 (5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase) for an association with a mother'...

Objective: To assess maternal serum amyloid A (SAA) levels among women with primary unexplainedrecurrent missed miscarriages.Patients and Method: prospective study (case control study) in Al-Zahraa Maternity Hospital, Najaf,Iraq, from first of January to the December 2019 was conducted 91 who weredivided into two groups:1. Group 1: Patient miscarriage early trimester at least consecutive primar...

Objective: The pathogenesis of human spontaneous abortion involves a complex interaction several genetic and environmental factors. Resistance to anticoagulant activity activated protein C (APC), often due point mutations in Factor V gene. Leiden mutation is definitely associated with pregnancy complications. In this study, we have investigated association factor recurrent miscarriage Iranian p...