background: hematopoietic stem cell transplantation (hsct) is currently the only curative treatment for acute leukemia. as hsct improves the long-term survival, it is necessary to assess the late-onset complications affecting the quality of life following hsct. subjects and methods: the study included 122 patients (65 male, 57 female) with leukemia (72 aml and 50 all) who received transplants f...

OBJECTIVE To discuss the role of allogeneic transplantation for the treatment of severe aplastic anemia. METHODS Published reports for treatment of severe aplastic anemia were searched with Medline. Search terms included severe aplastic anemia, HLA-matched sibling, unrelated donor, hematopoietic stem cell transplantation. RESULTS Survival after HLA-matched sibling donor transplantation is a...

HSCT was performed.6 John Goldman was widely respected in the fi eld of haematology and he was one of the pioneers who laid the foundation stones for the fi eld of unrelated donor marrow transplantation.7 Together with Professor Jon Van Rood, who made crucial discoveries in the role of HLA and laid the groundwork for the tissue typing that would make blood stem cell transplants possible, Profes...

INTRODUCTION We aimed to evaluate the intralobar renal arteries indexes using the Doppler ultrasonography indexes, which have become the established method of kidney monitoring, in living unrelated kidney donors during the postnephrectomy period. MATERIALS AND METHODS In this prospective study, we evaluated and followed up 34 living unrelated kidney donors. The Doppler ultrasonography indexes...

OBJECTIVE To assess donor morbidity, recipient outcome, and changing trends during the past decade in donor nephrectomy for living-donor kidney transplantation. DESIGN AND SETTING Retrospective review at an academic tertiary care referral center. PATIENTS We reviewed 201 consecutive living-donor kidney transplantations performed between January 1988 and June 1997. INTERVENTION Donor nephr...

Recognition of HLA incompatibilities by the immune system represents a major barrier to allogeneic hematopoietic stem cell transplantation. HLA genotypically identical sibling donors are, therefore, the gold standard for transplantation purposes, but only 30% patients have such a donor. For the remaining 70% patients alternative sources of stem cells are a matched unrelated adult volunteer dono...