INTRODUCTION Deep brain stimulation (DBS) nowadays is a well-established treatment of motor symptoms in Parkinson's disease. The subthalamic nucleus (STN) is a common target for DBS, because motor improvements have been shown to be superior to best medical therapy, if DBS electrodes have been appropriately positioned. DBS target identification can be assisted by MRI beyond structural imaging by...

introduction: one of the most common syndromes in parkinson's disease (pd) is rigidity. currently, an index is used to evaluate the level of pd by the clinical measurement of rigidity in the upper extremity. the index uses a subjective method called unified parkinson's disease rating system (updrs). the subjective nature of this method makes the influence of physician in the measureme...

Introdução: do ponto de vista clínico, são muitos os elementos para a deterioração da qualidade vida (QV) na Doença Parkinson (DP). Objetivo: analisar QV idosos com DP vinculados um programa atenção à saúde idoso. Metodologia: estudo transversal 11 DP. A foi avaliada por meio Parkinson’s Disease Questionary-39, incapacidade através Escala Hoehn Yahr modificada (HY). As partes I (estado mental),...

BACKGROUND We previously reported gut dysbiosis in patients with Parkinson's disease (PD). OBJECTIVE The aim of this study is to examine whether gut dysbiosis correlates with the progression of PD. METHODS We examined changes in gut microbiota and demographic features in 2 years in 36 PD patients. RESULTS A change of total UPDRS scores in 2 years was predicted by the counts of Bifidobacte...

Olfactory decline is a frequent and early non-motor symptom in Parkinson's disease (PD), which is increasingly used for diagnostic purposes. Another early appearing sign of PD consists in electroencephalographic (EEG) alterations. The combination of olfactory and EEG assessment may improve the identification of patients with early stages of PD. We hypothesized that olfactory capacity would be c...

Classical motor symptoms of Parkinson's disease (PD) such as tremor, rigidity, bradykinesia, and axial symptoms are graded in the Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) III. It is yet to be ascertained whether parkinsonian motor symptoms are associated with different anatomical patterns of neurodegeneration as reflected by brain grey matter (GM) alterati...

Deep brain stimulation (DBS) is the surgical procedure of choice for patients with advanced Parkinson disease (PD). We aim to evaluate the efficacy of GPi (globus pallidus internus), STN (subthalamic nucleus)-DBS and medical therapy for PD. We conducted a systematic review and multiple-treatments meta-analysis to investigate the efficacy of neurostimulation and medical therapy for PD patients. ...

INTRODUCTION & OBJECTIVES Adaptive deep brain stimulation (aDBS) uses feedback from brain signals to guide stimulation. A recent acute trial of unilateral aDBS showed that aDBS can lead to substantial improvements in contralateral hemibody Unified Parkinson's Disease Rating Scale (UPDRS) motor scores and may be superior to conventional continuous DBS in Parkinson's disease (PD). We test whether...

BACKGROUND Sleep disorders are highly prevalent among patients with Parkinson's disease (PD). Chronic medication with L-dopa may be one of the factors that contributes to poor sleep quality. The aim of this study was to assess the effects of long term use of L-dopa on objective and subjective measures of sleep quality in PD patients. METHODS Twenty-seven PD patients (mean age 62.5 ± 8.6 years...

BACKGROUND/AIM Selective serotonin reuptake inhibitors are the most commonly chosen antidepressants in patients with Parkinson's disease (PD). The aim of our study was to assess the influence of fluoxetine (Flu) on motor functions in patients with PD. METHODS In this prospective, controlled, open-label study, 18 patients with PD and mild depression [(10 < or = Hamilton Rating Scale for Depres...