نتایج جستجو برای: urate deposition
تعداد نتایج: 96523 فیلتر نتایج به سال:
DANTZLER, WILLIAM H. Churacteristics of urate transport by isolated pcrjused snake proximal renal tubules. Am. J. Physiol. 224(2) : 445-453. 1973.-Urate transport was studied in isolated, perfused snake ( Thamnophis spp. ) p roximal renal tubules in vitro. Secretion of urate from bath to tubule lumen occurred against a concentration gradient at flow rates varying from 0.08 to 7 nl/min. Urate tu...
In many crustaceans, changing concentrations of several low molecular weight compounds modulates hemocyanin oxygen binding, resulting in lower or higher oxygen affinities of the pigment. The nonphysiological effector caffeine and the physiological modulator urate, the latter accumulating in the hemolymph of the lobster Homarus vulgaris during hypoxia, increase hemocyanin oxygen affinity and dec...
Marked hyperuricemia is known to cause acute renal failure via intrarenal crystal deposition. However, recent studies suggest mild hyperuricemia may have vasoactive and proinflammatory effects independent of crystal formation. We therefore tested the hypothesis that mild hyperuricemia might exacerbate renal injury and dysfunction in a model of cisplatin-induced acute renal failure in the rat. C...
BACKGROUND Although epidemiological studies have reported positive associations between circulating urate levels and cardiometabolic diseases, causality remains uncertain. OBJECTIVES Through a Mendelian randomization approach, we assessed whether serum urate levels are causally relevant in type 2 diabetes mellitus (T2DM), coronary heart disease (CHD), ischemic stroke, and heart failure (HF). ...
BACKGROUND Rasburicase (Fasturtec® or Elitek®, Sanofi-Aventis), the recombinant form of urate oxidase from Aspergillus flavus, is a therapeutic enzyme used to prevent or decrease the high levels of uric acid in blood that can occur as a result of chemotherapy. It is produced by Sanofi-Aventis and currently purified via several standard steps of chromatography. This work explores the feasibility...
OBJECTIVES The aims of this study were to establish whether, in patients with gout, MPO is released from neutrophils and urate is oxidized to allantoin and if these effects are attenuated by allopurinol. METHODS MPO, urate, allantoin and oxypurinol were measured in plasma from 54 patients with gout and 27 healthy controls. Twenty-three patients had acute gout, 13 of whom were receiving allopu...
BACKGROUND The risk of Parkinson disease (PD) and its rate of progression may decline with increasing concentration of blood urate, a major antioxidant. OBJECTIVE To determine whether serum and cerebrospinal fluid concentrations of urate predict clinical progression in patients with PD. DESIGN, SETTING, AND PARTICIPANTS Eight hundred subjects with early PD enrolled in the Deprenyl and Tocop...
The specific effects of L-lactate and urate on oxygen binding by the haemocyanin of the lobster Homarus vulgaris were investigated. Increasing concentrations of L-lactate were found to increase haemocyanin oxygen-affinity. The relationship between the oxygen affinity (logP50) and [L-lactate] expressed as (Alog/5())(Alog[L-lactate])"' was -0.11 at L-lactate concentrations between 0.3 and 1 Immoi...
Gout is increasing in prevalence throughout the world, particularly in developed countries. The causes are dietary--purine-rich foods, high saturated fats, fructose-containing drinks and alcohol. Gout is also drug-related and associated with increased obesity, hypertension, insulin resistance and metabolic syndrome. Although very readily treated, there is evidence that physicians fail to optimi...
L-Lactate, the only known anaerobic end-product in decapod crustaceans (Gade, 1983), increases haemocyanin oxygen-affinity (Tnichot, 1980; Mangum, 1983; Bridges and Morris, 1986). In exercised blue crabs, Callinectes sapidus, the decrease in haemocyanin oxygen-affinity induced by metabolic acidosis via the Bohr shift was substantially balanced by the opposing effect of L-lactate (Booth etal, 19...
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