Alcohol and nicotine are the two most co-abused drugs in the world. Previous studies have shown that nicotine can increase alcohol drinking in nondependent rats, yet it is unknown whether nicotine facilitates the transition to alcohol dependence. We tested the hypothesis that chronic nicotine will speed up the escalation of alcohol drinking in rats and that this effect will be accompanied by ac...

conclusions present study demonstrated that the frequency of tobacco and substance abuse is considerable among iranian university students who thought to be more knowledgeable and concerned about their health. thus, efficient educational programs are needed to reduce the high-risk behaviors before students enter to university. background risky behaviors such as tobacco and substance abuse, whic...

The study examined models of marijuana (n = 309) and alcohol (n = 731) problems. Impulsivity was directly associated with both marijuana- and alcohol-related problems. Negative mood regulation expectancies were indirectly associated with marijuana problems through coping motives. Sensation seeking was indirectly associated with alcohol problems through enhancement motives. Affect lability and n...

Alcohol directly affects astroglial cell function, including inflammation-related activity.  And it also affects microglial cell development and function in specific ways that interfere with microglial interactions with the immune system and with neurons. Neuroinflammatory processes might be involved in alcohol-induced brain damage. Alcohol use, misuse and getting used to it causes differe...

sugar beet pulp is one of the sugar industries by-products which can be used for cellulase enzyme production, enzymatic saccharification, and alcohol production due to its high percentage of lingo-cellulosic content. trichoderma spp. is an important fungus that produces a wide range of cellulytic enzymes. in this study, cellulase enzyme was produced by placing sugar beet pulp in trichoderma fer...

BACKGROUND Cocaethylene (CE) is a cocaine metabolite formed during alcohol and cocaine co-consumption. There are no previous studies to assess the effectiveness of hair CE as a biomarker indicating chronic alcohol consumption among individuals who have consumed cocaine. OBJECTIVES To establish the ability of CE to predict chronic alcohol use among individuals testing positive for cocaine. M...

PURPOSE To determine easily identifiable risk factors that differentiate pregnant adolescents who report recent (past 30 days) alcohol use and those who discontinue use by their first prenatal visit from those who deny consuming alcohol altogether. METHODS A structured interview was completed by 378 adolescents < or = 17 years of age as part of standard care at our institution's adolescent ob...