easily degradating and various isomeric forms of rapamycin (sirolimus) face the determination of this compound to many challenges. in this study, we developed and validated the isocratic reversed phase high performance liquid chromatographic (rp-hplc) method for rapamycin. separation was performed on a c8 column (mz, 15 × 4.6 mm, 5 µm particle size) using methanol:water (80:20 v/v) as the mobil...

introduction : there is always concerns regarding postoperative bleeding in coronary artery bypass graft (cabg) patients; a number of different strategies have been used to compensate for it and to reduce the amount of blood transfusion. we designed this study to see if local fibrinogen could decrease postoperative bleeding in adult cabg, which is not studied yet. materials and methods : in a d...

a gradient reversed-phase high performance liquid chromatography (hplc) method was developed for the assay of cetrorelix acetate, a synthetic decapeptide with gonadotropin-releasing hormone (gnrh) antagonistic activity used in infertility treatment. the hplc method, which is used to determine cetrorelix in bulk and pharmaceutical dosage forms, was validated per ich guidelines. the chromatograph...

background: teat lacerations are serious injuries thatendanger the survival of a cow within the herd. in excessivelacerations, the wound should be left to heal by second intentionhealing process. however, tissue contraction during healing canchange the alignment of the teat, creating problems for machinemilking. objectives: the purpose of the present study was toevaluate the transplantation of ...

conclusions physical or physiological and psychological stressors impose greater stress and are predictors of anxiety. when preparing their nursing care plan, nurses should consider these stressors that affect anxiety levels in patients undergoing cabg surgery and those hospitalized in intensive care units. patients and methods this is a descriptive-analytical study that uses a non-random conve...

background platelet rich plasma is known for its hemostatic, adhesive and healing properties in view of the multiple growth factors released from the platelets to the site of wound. the primary objective of this study was to use autologous platelet rich plasma (prp) in wound beds for anchorage of skin grafts instead of conventional methods like sutures, staplers or glue. methods in a single cen...

background cartilage tissue has limited regenerative capacity and the management of cartilage defects has always been a challenging issue. platelet-rich plasma (prp) has been recently been used to improve healing of cartilage defects. in the present experiment, we aimed to investigate the effects of prp on regeneration capacity as well as survival of the cartilage grafts in a rabbit model. meth...

aim and background: coronary artery bypass graft (cabg) surgery is the most common surgical procedure for patients suffering from coronary artery diseases. many studies demonstrated cabg as a serious crisis for patients resulting in excessive stress and anxiety. this study was performed to assess the effects of reflexology on anxiety levels among cabg surgery candidates in shahid chamran hospit...

background: kidney transplantation is a preferred treatment for many patients with end-stage renal disease (esrd) and is far more profi table than hemodialysis. analyzing renal transplantation data can help to evaluate the eff ectiveness of transplantation interventions. the aim of this study was to determine the organ survival rate after kidney transplantation during a period of 10 years (marc...