نتایج جستجو برای: vaccine potency
تعداد نتایج: 133954 فیلتر نتایج به سال:
Subunit vaccines often require adjuvants to elicit sustained immune activity. Here, a method is described to evaluate the efficacy of single vaccine candidates in the preclinical stage based on cytokine and gene expression analysis. As a model, the recombinant human respiratory syncytial virus (RSV) fusion protein (RSV-F) was produced in CHO cells. For comparison, wild-type and glycoengineered,...
RNA-based vaccines have recently emerged as a promising alternative to the use of DNA-based and viral vector vaccines, in part because of the potential to simplify how vaccines are made and facilitate a rapid response to newly emerging infections. SAM vaccines are based on engineered self-amplifying mRNA (SAM) replicons encoding an Ag, and formulated with a synthetic delivery system, and they i...
BACKGROUND Child immunisation is among the most cost-effective ways of preventing premature child deaths, and the potency of vaccines, crucial for vaccine efficacy, is dependent on effective management of the cold chain at all levels of vaccine handling. OBJECTIVE To assess the status of the cold chain at peripheral vaccine stores in Ethiopia. DESIGN Institution based cross-sectional survey...
Significance Two major serotypes of Vibrio cholerae circulate globally and cause pandemic cholera, but how infection or vaccination with each serotype impacts immune responses subsequent protection against future by the pathogen is not well-known. We engineered matched variants a new oral cholera vaccine candidate, HaitiV, to investigate effect variation on immunogenicity protective efficacy. O...
Whole cell pertussis vaccine was prepared by inactivation of Bordetella pertussis organisms with glutaraldehyde under optimal conditions (0.05% glutaraldehyde at room temperature for 10 minutes). This glutaraldehyde inactivated pertussis vaccine-1 (GIPV-1) was compared to the routinely produced heat inactivated (56°C for 30 minutes) pertussis vaccine (HIPV) for potency, toxicity and immunogenic...
The Bacille Calmette-Guérin (BCG) is live and attenuated strain of Mycobacterium bovis which is used throughout the world as vaccine against tuberculosis. BCG vaccination contributes to the prevention and control of tuberculosis in limited situations when other strategies are inadequate. As there is currently no alternative, BCG will continue to be used in future as vaccine and also as a prime ...
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