نتایج جستجو برای: vascular endothelial growth factor vegf
تعداد نتایج: 1689345 فیلتر نتایج به سال:
INTRODUCTION The aim of this study is to determine whether regulation of the expression level of fms-like tyrosine kinase-4 (Flt-4) is related to osteoclast differentiation. MATERIAL AND METHODS Osteoclast formation and differentiation of mouse bone marrow cells and RAW264.7 cells were performed. To induce osteoclast differentiation, RANKL (50 ng/ml) with or without vascular endothelial growt...
OBJECTIVE Recently, we reported that the forkhead transcription factor, FKHR/FOXO1, is required for vascular endothelial growth factor (VEGF)-mediated upregulation of a number of genes in endothelial cells. Here, we tested the hypothesis that hepatocyte growth factor (HGF), a potent activator of PI3K-Akt in endothelial cells, is capable of depleting the nucleus of FKHR/FOXO1 and thus inhibiting...
BACKGROUND Vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) induces both angiogenesis and vascular permeability. Although its angiogenic activity has been well characterized, the signaling pathways of VEGF-induced permeability remain poorly understood. METHODS AND RESULTS Using the mouse corneal micropocket assay, Miles assay, and a combination of cytochemical, elect...
background: crimean-congo hemorrhagic fever (cchf) is a disease characterized by serious course, including acute viral fever, ecchymosis, thrombocytopenia, liver dysfunction and high rate of mortality. hypoxia inducible factor-1α (hif-1α) and vascular endothelial growth factor-a (vegf-a) play an important role both in the inflammatory process and plasma leakage. the aim of this study was to de...
Abstract We evaluated changes in the complement system resulting from anti-vascular endothelial growth factor (VEGF) eyes with age-related choroidal neovascularization (CNV) including neovascular macular degeneration, pachychoroid neovasculopathy, and polypoidal neovasculopathy. measured concentrations of activation products (C3a, C4a), VEGF, monocyte chemotactic protein-1 aqueous humor during ...
Vascular permeability factor (VPF)/vascular endothelial growth factor (VEGF) is unique in its ability to promote vascular permeability and endothelial cell growth, and its role in tumor development has received considerable attention. In this report, we describe the elevation of VPF/VEGF transcript expression in human hepatocellular carcinoma. Surgical samples of 23 patients with hepatocellular...
RATIONALE Vascular endothelial growth factor (VEGF) is the main driver of angiogenesis and vascular permeability via VEGF receptor 2 (VEGFR2), whereas lymphangiogenesis signals are transduced by VEGFC/D via VEGFR3. VEGFR3 also regulates sprouting angiogenesis and blood vessel growth, but to what extent VEGFR3 signaling controls blood vessel permeability remains unknown. OBJECTIVE To investiga...
زمینه و هدف : هدف این مطالعه مروری بر درمان های دارویی ادم سیستوئید ماکولای سودوفیکیک بود. روش کار : این بررسی، مروری سیستماتیک بر روش های درمانی پذیرفته شده در ادم سیستوئید ماکولای سودوفیکیک ( pseudophakic cystoid macular edema: pcme )است. پارامترهای سنجش شامل حدت بینایی و اندازه گیری ضخامت مرکز شبکیه (ماکولا) توسط توموگرافی کوهرنس نوری ( optical coherence tomography: oct ) می باشند. جستجوی ...
the most important progress in the field of retinal diseases during recent years might be the introduction of pharmacotherapy. age-related macular degeneration for instance was an irreversible disease leading to permanent anatomical and functional changes in the macula up to the previous decade; however, the use of anti-vascular endothelial growth factor agents (anti-vegfs) not only stops the p...
Betts et al (2011) reported that Rb1 inhibits vascular endothelial growth factor (VEGF) release by retinal pigment epithelial cells, which is a major source of VEGF in the eye (1). Vascular endothelial growth factor is a proangiogenic cytokine that contributes significantly to pathological retinal and choroidal neovascularization in association with diabetic retinopathy and age-related macular ...
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