AS GENERALLY agreed, the magnitude . of coronary flow is determined by the pressure head at the coronary ostia, the vasomotor tonus of the coronary vessels, and the compression exerted upon the intramural vessels by the beating heart muscle (not considering here: blood viscosity, coronary venous pressure, and certain other factors). Coronary flow is usually more than sufficient to supply the he...

Coronary vasomotor function plays an important role in onset and progression of coronary artery disease. Suwaidi [Circulation 101 (2000) 948] and Schächinger [Circulation 101 (2000) 1899] demonstrated that vasomotor dysfunction has a significant impact on events in patients with minimal coronary artery disease. Endothelial specific testing can be performed in coronary as well as peripheral arte...

Several observers have directed attention to the frequent occurrence of vasomotor disturbances in patients with paroxysmal hemoglobinuria, and a few (1, 2, 3, 4, 5) have suggested that these disturbances are of importance in the pathogenesis of the disease. The purpose of this communication is to present observations on a patient with paroxysmal hemoglobinuria which demonstrate that the sympath...

Adiponectin, an adipocyte-derived protein, has been shown to have vasculoprotective effects. This study examined the possible relationship between coronary vasomotor function and the transcardiac gradient of adiponectin, reflecting adiponectin utilization and/or accumulation in the coronary vascular bed. The epicardial diameter and blood flow response of the left anterior descending coronary ar...

Disturbances of vasomotor responses of the feet have been reported by Wenckebach (1), Weiss and Wilkins (2), and Wilkins and Kolb (3) among patients suffering with peripheral neuritis, associated with vitamin deficiency. The latter investigators stated that the disturbance was characterized by a decrease of the vasomotor tonus of the feet, resembling that found after resection of the first and ...

A method is described for eliciting fingertip vasomotor reflexes by inspiratory gasp and contralateral hand cold challenge. The results of the two tests are reproducible on replicate testing and, when taken together, have proved reliable for detection of impairment of autonomic reflexes in 10 newly registered leprosy patients who did not have any obvious deformity. Similar, but less severe, imp...

Tetraethylammonium (TEA) given intravenously decreases peripheral vascular resistance. The magnitude of the decrement is related directly to the prevailing level of neurogenic vasomotor tone. TEA was administered to hypertensive and normotensive subjects. The decrements in resistance of the foot did not differ between the two groups. The decrements of the forearm also did not differ. These find...

THE ROSTRAL VENTROLATERAL MEDULLA (RVLM) plays a critical role in the maintenance of baseline arterial pressure (AP) in all species in which it has been examined, and it appears to be the primary site responsible for the tonic supraspinal drive of sympathetic vasomotor outflow and AP, at least in anesthetized animals. For example, inhibition of the RVLM in anesthetized rats, cats, and rabbits r...

BACKGROUND AND OBJECTIVE In patients with alcohol dependence, ethyl-toxic damage of vasomotor and cardiac autonomic nerve fibers leads to autonomic imbalance with neurovascular and cardiac dysfunction, the latter resulting in reduced heart rate variability (HRV). Autonomic imbalance is linked to increased craving and cardiovascular mortality. In this study, we sought to assess the effects of HR...