نتایج جستجو برای: vasopressin type 2 receptor
تعداد نتایج: 3791004 فیلتر نتایج به سال:
Polycystic kidney diseases (PKDs) are genetic disorders that can cause renal failure and death in children and adults. Lowering cAMP in cystic tissues through the inhibition of the type-2 vasopressin receptor (V2R) constitutes a validated strategy to reduce disease progression. We identified a peptide from green mamba venom that exhibits nanomolar affinity for the V2R without any activity on 15...
Recently, considerable evidence has been accumulated to support the novel view that water homeostasis in the inner ear is regulated via the vasopressin-aquaporin 2 (VP-AQP2) system in the same fashion as in the kidney. Indeed, multiple subtypes of AQPs including AQP-2 are reported to be expressed in the cochlea. However, the mechanism that underlies VP-AQP-2 mediated water homeostasis remains t...
Cross-talk between the phospholipase C and adenylyl cyclase signalling pathways was investigated in Chinese hamster ovary (CHO) cells transfected with the V1a and V2 vasopressin receptors. Cell lines expressing V1a, V2, or both V1a and V2 receptors, were established and characterized. Stimulation of V2 receptors by vasopressin induced a dose-dependent increase in cAMP accumulation, whereas stim...
Bilateral common carotid occlusion (BCO) over a period of 60 s in conscious rats produces a biphasic pressor response, consisting of an early (peak) and late (plateau) phase. In this study we investigated 1) the effects of lesions of the commissural nucleus of the solitary tract (commNTS) on the cardiovascular responses produced by BCO in conscious rats and 2) the autonomic and humoral mechanis...
Arginine vasopressin plays an important role in the regulation of social behaviours in rodents. In the Syrian hamster, vasopressin injected directly into the brain stimulates scent marking and aggressive behaviour in a steroid dependent manner and is therefore a useful model for investigating steroid-peptide-behaviour interactions. In this study, we used in situ hybridization and radioligand bi...
1. Abstract 2. Introduction 3. AP-1 as a transcription factor 4. Defining AP-1-driven gene expression in the brain: technical considerations 5. Putative AP-1 target genes 5.1. Genes encoding the transmembrane and extracellular proteins 5.1.1. Tissue inhibitor of metalloproteinases-1 (timp-1) 5.1.2. Growth-associated protein 43 (GAP-43, B50, neuromodulin, F1, PP46) 5.1.3. Angiotensin II type 1 r...
The reduced pressure response to vasopressin during acute sepsis has directed our interest to the regulation of vasopressin V(1A) receptors. Rats were injected with lipopolysaccharide for induction of experimental gram-negative sepsis. V(1A) receptor gene expression was downregulated in the liver, lung, kidney, and heart during endotoxemia. Inasmuch as the concentrations of proinflammatory cyto...
Höcherl K, Schmidt C, Kurt B, Bucher M. Inhibition of NFB ameliorates sepsis-induced downregulation of aquaporin-2/V2 receptor expression and acute renal failure in vivo. Am J Physiol Renal Physiol 298: F196–F204, 2010. First published October 14, 2009; doi:10.1152/ajprenal.90607.2008.—Acute renal failure (ARF) is frequently associated with polyuria and urine concentration defects and it is a s...
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