in addition to increment of the vehicle sprung mass, the main physical effects of addition of cng tank to the vehicle are the longitudinal and height displacement of center of gravity, which have the most influences on the handling, braking, roll stability and spin stability of the vehicle. increment of cng tank mass to the sprung mass of the vehicle increases the vehicle under-steer gradient, ...

Lipotoxicity associated with insulin resistance is central to nonalcoholic steatohepatitis (NASH) pathogenesis. To date, only weight loss fully reverses NASH pathology, but mixed peroxisome proliferator-activated receptor-alpha/delta (PPAR-α/δ) agonists show some efficacy. Seladelpar (MBX-8025), a selective PPAR-δ agonist, improves atherogenic dyslipidemia. We therefore used this agent to test ...

Vitamin D3 (100 ng 100 g body weight-1 day-1) was administered intraperitoneally (i.p.) to the freshwater mud eel Amphipnous cuchia kept in artificial freshwater, calcium-free freshwater, low-calcium freshwater (0.2 mmol/l CaCl2) or calcium-rich freshwater (13.4 mmol/l CaCl2) for 15 days. Analyses of serum calcium and phosphate levels were performed on days 1, 3, 5, 10 and 15 after the beginnin...

Increased intracellular cyclic AMP (cAMP) in renal tubular epithelia accelerates the progression of polycystic kidney disease (PKD). Thus, decreasing cAMP levels by an adenylyl cyclase inhibitory G protein activator is considered to be an effective approach in ameliorating PKD. In fact, pasireotide (PAS) was effective in reducing disease progression in animal models of PKD. However, hyperglycem...

The melanocortin system is a critical pathway in the regulation of energy balance. In this study, we analyzed the peripheral effects of the synthetic melanocortin agonist melanotan-II (MT-II) in rodents fed a low-fat or high-fat diet. MT-II-treated high-fat diet-induced obese (DIO) mice lost weight and body fat, whereas MT-II-treated low-fat-fed mice maintained their original body weight. Speci...

Concentrations of polybrominated diphenyl ethers (PBDEs) in Forster's tern (Sterna forsteri) eggs from San Francisco Bay have been reported to range up to 63μgg(-1) lipid weight. This value exceeds the lowest-observed-adverse-effect level (1.8μgg(-1) egg wet weight; ∼32μg(-1) lipid weight) reported in an embryotoxicity study with American kestrels (Falco sparverius). As a surrogate for Forster'...

To investigate the toxic effects of cheonggukjang (CKJ) manufactured using mixed cultures of Bacillus subtilis MC31 and Lactobacillus sakei 383 on the liver and kidney of ICR mice, an alteration on the related markers including body weight, organ weight, urine composition, liver pathology and kidney pathology were analyzed after oral administration at dosage of 25, 50 and 100 mg/kg body weight/...

To evaluate the hepatotoxicity and nephrotoxicity of Galla Rhois (GR) toward the liver and kidney of ICR mice, alterations in related markers including body weight, organ weight, urine composition, liver pathology and kidney pathology were analyzed after oral administration of 250, 500 and 1,000 mg/kg body weight/day of gallotannin-enriched extract of GR (GEGR) for 14 days. GEGR contained 68.7±...

Aiming at the negative vibration effect caused by increased unsprung mass of hub motor-air suspension (HM-AS) vehicle and unbalanced magnetic force (UMF) motor, a linear quadratic regulator (LQR) air control strategy based on genetic algorithm is proposed. Considering coupling road surface excitation UMF, model HM-AS established. Then, according to optimal theory algorithm, LQR controller desig...

Heavy-duty diesel vehicles contribute a substantial fraction of nitrogen oxides and particulate matter to on-road vehicle emission inventory. The objectives of this study are to estimate roadway link-based emission rates for heavy-duty trucks for use in emission inventory estimation, and to quantify the impact of factors affecting truck emissions. A speed-acceleration modal emissions approach i...