UNLABELLED Recent advances in proteomics enable deep profiling of the compositional details of snake venoms for improved understanding on envenomation pathophysiology and immunological neutralization. In this study, the venom of Australian tiger snake (Notechis scutatus) was trypsin-digested in solution and subjected to nano-ESI-LCMS/MS. Applying a relative quantitative proteomic approach, the ...

: The venoms of Tunisian wildlife snakes are complex mixtures containing proteins/ peptides and non-protein molecules. Proteins the most abundant compounds responsible for biological effects venoms. Snake proteins have enzymatic or nonenzymatic activities, which grouped into different families, including C-type lectin proteins, disintegrins (long, medium short disintegrins), Kunitz-type serine ...

We report the proteomic characterization of the venoms of two closely related pit vipers of the genus Lachesis, L. muta (South American Bushmaster) and L. stenophrys (Central American Bushmaster), and compare the toxin repertoire of the former revealed through a proteomic versus a transcriptomic approach. The protein composition of the venoms of Lachesis muta and L. stenophrys were analyzed by ...

1. Chromatography on silica gel, combined with infrared spectrometry, has been used to analyse mixtures of bile acids. 2. The results obtained by applying this method to an ox bile-salt preparation are described. Methyl lithocholate (methyl 3-hydroxycholanate) (1.8 mg.), methyl deoxycholate (methyl 3:12-dihydroxycholanate) (38 mg.), methyl chenodeoxycholate (methyl 3:7-dihydroxycholanate) (0-6 ...

background: snakebite is a serious public health problem in the world. the annual incidence of snakebites ranges from 4.5-9.1 in 100,000 population in iran. with regard to diversity of envenomation profiles in different geographical parts of iran, the aim of this study was to determine the demographical data, clinical and laboratory findings, and the outcome of the snakebite victims referred to...

tarantulas have recently become as pets in most parts of the world that increased the probability of encountering emergency physicians with patients hurt with these spiders. their attacks usually do not cause general manifestation, however there are some case reports in this regard. here, a 40-year-old man was reported who was referred to the emergency department with severe periumbilical pain ...

Platelet aggregation inhibitory effect and anticoagulant properties of fractions separated from the venoms of Cerastes persicus fieldi and Echis carinatus were investigated. The partial fractionation was performed on a Sephadex G-100 column. Two fractions separated from Cerastes persicus fieldi showed anti platelet aggregation activity on ADP (200 µM)-induced platelet aggregation (ca 80% inhibi...