OBJECTIVES To determine the efficacy of risedronate in reducing vertebral fracture risk in women aged 80 and older with osteoporosis. DESIGN Pooled analysis of data from three randomized, double-blind, controlled, 3-year-fracture-endpoint trials conducted from November 1993 to April 1998: Hip Intervention Program (HIP), Vertebral Efficacy with Risedronate Therapy-Multinational (VERT-MN), and ...

OBJECTIVE Our objective was to analyze the relationship between bone mineral density (BMD) changes and fracture incidence during 3-yr treatment with strontium ranelate. PATIENTS Women from the strontium ranelate arm of the Spinal Osteoporosis Therapeutic Intervention study and the TReatment Of Peripheral OSteoporosis study were evaluated. OUTCOME MEASURES The outcome measures included BMD a...

Recently, it has been suggested that there is a close link between bone and energy metabolism through osteocalcin and the Wnt/β-catenin signaling pathway. In clinical settings, accumulating evidence has shown an association between type 2 diabetes and osteoporosis. However, patients with type 2 diabetes have high fracture rates despite the absence of low bone mineral density [1]. In this contex...

BACKGROUND Treatment guidelines recommend drug treatment to prevent fractures for some postmenopausal women who have low bone mass (osteopenia) but do not have osteoporosis or a history of clinical fractures. OBJECTIVE To estimate the societal costs and health benefits of alendronate drug treatment to prevent fractures in postmenopausal women with osteopenia. DESIGN Markov model with 8 heal...

Selective estrogen receptor modulators (SERMs), which exhibit estrogen receptor agonist or antagonist activity based on the target tissue, have evolved through multiple generations for the prevention and/or treatment of postmenopausal osteoporosis. An ideal SERM would protect bone without stimulating the breast or endometrium. Raloxifene, lasofoxifene, and bazedoxifene have demonstrated unique ...

Childhood fractures are common. Their clinical relevance to osteoporosis and fractures in later life is unclear. The aim of this study was to determine the predictive risk of childhood fracture on the risk of fracture in later life. Men and women >or=50 yr of age were recruited from population registers for participation in the European Prospective Osteoporosis Study (EPOS). Subjects completed ...

BACKGROUND Little empirical research has examined the multiple consequences of osteoporosis on quality of life. METHODS Health related quality of life (HRQL) was examined in relationship to incident fractures in 2009 postmenopausal women 50 years and older who were seen in consultation at our tertiary care, university teaching hospital-affiliated office and who were registered in the Canadian...

Vertebral fracture, the hallmark of osteoporosis, usually occurs in postmenopausal women with low bone mineral density (BMD). The aim this study was to determine which BMD parameter can best predict women at high risk of fracture. BMD values at the spine and femoral neck were compared in 34 women with vertebral fracture and 34 controls. Mean BMD (g/cm2), T-score, and Z-score values at both femo...

BACKGROUND Previous studies from our group have shown that a high prevalence of vertebral deformities suggestive of fracture can be found in patients with an inflammatory disease, despite a near normal bone mineral density (BMD). As quantitative ultrasound (QUS) of the heel can be used for refined assessment of bone strength, we evaluated whether QUS can be used to identify subjects with an inf...

SINCE the first description of vertebroplasty in 1987 for the treatment of aggressive hemangiomas (1), vertebroplasty has become established as a safe and effective, minimally invasive procedure that offers a therapeutic option for patients with back pain from osteoporotic or tumor-related fractures. This initial success has spawned additional techniques for percutaneous vertebral augmentation,...