Several lines of evidence suggest that brain histamine may be involved in the central control of food intake. The effect of histamine on feeding is mediated through three kinds of receptors (H1, H2, and H3). The present study was designed to investigate the effect of intracerebroventricular injection of histamine, promethazine (H1 antagonist) and ranitidine (H2 antagonist) on food intake of fre...