Description Vinpocetine (vinpocetine-ethyl apovincaminate) was synthesized in the late 1960s from the alkaloid vincamine, extracted from the leaf of the lesser periwinkle plant (Vinca minor). Vinpocetine was made available under the trade name Cavinton in 1978 and has since been used widely in Japan, Hungary, Germany, Poland, and Russia for the treatment of cerebrovascular-related pathologies. ...

Recently detected but unidentified cytokinin activity in crown gall tumor tissue from Vinca rosea L. grown on media containing sources of reduced nitrogen has now been attributed to two adenine-type cytokinins. These compounds are glucopyranosyl derivatives of zeatin and ribosylzeatin. The substitution in each case is on the isopentenyl chain of the parent compound. Neither of these compounds h...

A series of Vinca alkaloids were found to block polymerization of crude tubulin extracts of porcine brain in a dose-dependent manner. This appears to be a specific effect occurring at low concentrations of drug. The concentration of vinblastine that prevents polymerization by 50% was 4.3 x 10(-7) mole/liter for a tubulin concentration of 3.0 mg/ml, and this concentration is consistent with leve...

Alopecia areata is common scalp complaint, seen in any age group. It an auto immune disorder effecting the hair follicles, causing loss of patches. constitutes a life time risk approximately 2%. does not carry significant sex or ethnic predominance. Peak incidence occurs second and third decades most patients experience onset before fourth decade. Homoeopathy 2nd widely used therapy all over wo...

Inadvertent intrathecal vincristine administration causes fatalities.