INTRODUCTION Neuroconstructivist theories of development highlight the potential effect one developmental domain may have on constraining or facilitating another. Empirical validation of this theory requires further testing in autism spectrum disorders (ASD), and may illuminate the complex interplay of developmental trajectories, particularly in the relationship between predictor and outcome va...

OBJECTIVE To describe the activities and participation of children with cerebral palsy and to examine the relationship with personal factors and disease characteristics. DESIGN Cross-sectional study. SETTING Department of Rehabilitation Medicine of a University Medical Center in The Netherlands. SUBJECTS One hundred and ten children: 70 boys, 40 girls, mean (SD) age 11 years and 3 months ...

Background: Children with autism should interact and get along with their surrounding environment. Therefore, the researchers must try to explain the reasons of challenges in their adaptive behaviors. This study aimed to evaluate levels of challenges in sensory processing and the motor domain of adaptive behavior among children with autism in Egypt, and to explore the effect of sensory processi...

OBJECTIVES This preliminary study examined sensory processing and its relationship to occupational performance in children with fragile X syndrome (FXS) to guide research and evidence-based practice. METHOD Fifteen school-aged boys with full-mutation FXS were assessed with three occupational performance measures (School Function Assessment, Vineland Adaptive Behavior Scales, play duration) an...

In Tuberous sclerosis complex (TSC), neurological dysfunction, usually in association with epilepsy, is responsible for the greatest degree of disease-related disability. Epilepsy surgery is increasingly recognized as a therapeutic option given the often medication-resistant nature of the disease. Seven subjects with medically refractory epilepsy associated with TSC, who underwent surgery at a ...

OBJECTIVES Periventricular hemorrhagic infarction is a serious complication of germinal matrix-intraventricular hemorrhage in premature infants. Our objective was to determine the neurodevelopmental and adaptive outcomes of periventricular hemorrhagic infarction survivors and identify early cranial ultrasound predictors of adverse outcome. METHODS We retrospectively evaluated all cranial ultr...

AIM The aim of this study was to describe the course of motor performance and analyse its relationship with motor capacity over a period of 3 years in 104 children (66 males, 38 females; 43% of those initially invited) with cerebral palsy (CP) aged 9, 11, and 13 years at the start of the study. Forty-one had hemiplegia, 42 diplegia, 21 tetraplegia; 83 spastic CP, 17 dyskinetic/mixed, and four a...

BACKGROUND Phthalates are endocrine-disrupting chemicals that influence thyroid hormones and sex steroids, both critical for brain development. AIM We studied phthalate concentrations in house dust in relation to the risks of developing autism spectrum disorder (ASD) or developmental delay (DD). METHODS Participants were a subset of children from the CHARGE (CHildhood Autism Risks from Gene...

PURPOSE Sex chromosome trisomies (SCTs) are found on amniocentesis in 2.3-3.7 per 1000 same-sex births, yet there is a limited database on which to base a prognosis. Autism has been described in postnatally diagnosed cases of Klinefelter syndrome (XXY karyotype), but the prevalence in non-referred samples, and in other trisomies, is unclear. The authors recruited the largest sample including al...

BACKGROUND Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting more than 1% of children. It is characterized by social communication deficits and repetitive behaviors/restricted interests. In the absence of any medications known to improve core symptom domains, parents often use complementary alternative treatments, including omega-3 fatty acid supplements. METHODS We co...