BACKGROUND The normalized dilute Russell viper venom time (DRVVT) ratio provides a robust assay methodology for lupus anticoagulant (LA) detection. OBJECTIVES We evaluated six normalized DRVVT LA screen and confirm systems for inter-method consistency. Reagents were purchased from Diagnostica Stago, Inc. (Parsippany, NJ); Precision BioLogic Inc. (Halifax, Nova Scotia, Canada); Siemens Healthc...

The studies on the morphology of lesions produced and the blood coagulation disturbances after Russell viper envenomation were studied in guinea pigs. The study showed very little morphological changes but the coagulation studies revealed disturbances in coagulation mechanism. The exact pathological process operating in Russell viper emvenomation needs further studies including the histochemica...

INTRODUCTION Russell's viper (Daboia russelii) is one of the most common medically important snakes reported in Sri Lanka. Its envenomation leads to significant mortality and morbidity with local, hematological, neurological and renal complications. Here we report the case of a patient who presented with bilateral blindness secondary to a bilateral posterior circulation ischemic stroke instead ...

Viperfav(TM) is a commercial F(ab')₂ antivenom prepared against European vipers venom. It is safe and effective for treating envenomation caused by Vipera aspis and Vipera berus. Therapeutic efficacy for treating Vipera ammodytes ammodytes (V. a. ammodytes) envenoming has not been yet described, although protective efficacy has been demonstrated in preclinical studies. We report on a 32-year-ol...

Recent reports have suggested that thromboplastin (Tpl) prepared from lung may reflect more accurately than does brain Tpl the changes produced in the prothrombin complex by coumarin derivatives (1, 2). As evidence for this, it has been observed that as factor VII concentration decreases in the plasma of Dicumarol '-treated patients, the prothrombin time obtained with lung Tpl becomes dispropor...

The action of the venom of the gaboon viper (Bitis gabonica) on blood coagulation, platelets, and the fibrinolytic enzyme system was studied. The results confirm that the venom of Bitis gabonica has a marked anticoagulant action in vitro. The venom appears to impair clot formation by a direct proteolytic action on fibrinogen, releasing soluble breakdown products.

When the term “disintegrin” was first coined in 1990, it described a family of naturally occurring proteins with low molecular weights and highly conserved sequences, both in their cysteine arrangements and adhesive Arg-Gly-Asp (RGD) motifs. Another common characteristic was the inhibitory potential these proteins demonstrated in interacting with cell-surface integrin receptors. Measurement of ...

The numerous components of the venoms various animal species cause an extremely wide range effects and symptoms in recipient’s body. At same time, degree severity pathological changes is determined, general, by type animal, volume method toxin administration, as well characteristic features victim. Changes structural functional parameters wall jejunum under influence viper venom are still poorl...

The article examines the ecological and biological significance of action animal poisons as an evolutionary adaptation that maximizes more than 250,000 species to conditions their habitat. It was found have a significant impact on formation course various forms connections in ecosystems, perform several functions are important biotic factors environment. best-studied venomous animals been be sn...

Background Snake venom composition is dictated by various ecological and environmental factors, can exhibit dramatic variation across geographically disparate populations of the same species. This molecular diversity undermine efficacy snakebite treatments, as antivenoms produced against from one population may fail to neutralise others. India world’s hotspot, with 58,000 fatalities 140,000 mor...