Abstract Interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) can restrict viral pathogens, but pro- anti-viral activities have been reported for coronaviruses. Here, we show that artificial overexpression of IFITMs blocks SARS-CoV-2 infection. However, endogenous IFITM expression supports efficient infection in human lung cells. Our results indicate the Spike protein interacts with hi...

Several phytochemicals exhibited high level of antiviral activity. Medicinal plant possessed activity via many mechanisms included inhibition viral replication, the assembly intracellular infectious virus particles, infectivity, RNA polymerase, DNA neuraminidase, protease, reverse transcriptase and protein expression other mechanisms. The current review discuss medicinal plants with their action.

Viruses are prominent examples of symmetry in biology. A better understanding and breaking virus structure via mathematical modelling opens up novel perspectives on how viruses form, evolve infect their hosts. In particular, models viral pave the way to forms antiviral therapy exploitation protein containers bio-nanotechnology.

objective: dna vaccines have been widely used to develop immunity against various pathogens including parasites and viruses. the potential of dna vaccine to induce an effective immune response is related to the expression levels of the encoded protein in eukaryotic cells. therefore, optimization of plasmid dna delivery system is a major concern in protein expression in order to make an efficien...

Noroviruses produce viral RNAs lacking a 5' cap structure and instead use a virus-encoded viral protein genome-linked (VPg) protein covalently linked to viral RNA to interact with translation initiation factors and drive viral protein synthesis. Norovirus infection results in the induction of the innate response leading to interferon stimulated gene (ISG) transcription. However, the translation...

Viruses are obligate, intracellular parasites that depend on host cells for successful propagation. Upon infection of host cells, positivestrand RNA viruses exploit and hijack cellular machinery and reprogram these cells into viral "factories" through various protein-protein, protein- RNA, and protein-lipid interactions. The molecular interplay between host factors and invading viruses is a con...