Mutational activation of cytokine receptors has been described in solid cancers but has not been generally known to drive acute leukemia. We have recently described a subgroup of acute lymphoblastic leukemia characterized by an aberrant expression of the receptor to the cytokine thymic stromal lymphopoietin (TSLP). This receptor is a heterodimer of CRLF2 and IL7RA. In addition to its aberrant e...

One hundred years ago a young Russian scientist, Dimitri Ivanovsky (1864 to 1920), presented a paper before the Academy of Sciences of St. Petersburg in which he stated that "the sap of leaves infected with tobacco mosaic disease retains its infectious properties even after filtration through Chamberland filter candles" (10). This observation suggested a disease agent smaller than any known bef...

a Department of Pathobiological Sciences, School of Veterinary Medicine, Influenza Research Institute, University of Wisconsin, Madison, WI 53711, United States b Laboratory of Virology, Division of Intramural Research, National Institutes of Health, Hamilton, MT 59840, United States c Department of Microbiology and Immunology, Division of Virology, International Research Center for Infectious ...

Metagenomic next-generation sequencing (mNGS) is an untargeted technique for determination of microbial DNA/RNA sequences in a variety sample types from patients with infectious syndromes. mNGS still its early stages broader translation into clinical applications. To further support the development, implementation, optimization and standardization procedures virus diagnostics, European Society ...