نتایج جستجو برای: virus therapy

تعداد نتایج: 1020983  

Journal: :Brazilian Journal of Infectious Diseases 2012

Journal: :Japanese Journal of Pharmacology 1998

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2015
W Hans Meisen Eric S Wohleb Alena Cristina Jaime-Ramirez Chelsea Bolyard Ji Young Yoo Luke Russell Jayson Hardcastle Samuel Dubin Kamaldeen Muili Jianhua Yu Michael Caligiuri Jonathan Godbout Balveen Kaur

PURPOSE Oncolytic herpes simplex viruses (oHSV) represent a promising therapy for glioblastoma (GBM), but their clinical success has been limited. Early innate immune responses to viral infection reduce oHSV replication, tumor destruction, and efficacy. Here, we characterized the antiviral effects of macrophages and microglia on viral therapy for GBM. EXPERIMENTAL DESIGN Quantitative flow cyt...

Journal: :Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2001
J M Kilby

Although plasma virus load is invaluable for monitoring human immunodeficiency virus (HIV) infection, key pathogenesis events and most viral replication take place in lymphoid tissues. Decreases in virus load associated with therapy occur in plasma and tissues, but persistent latent infection and ongoing viral replication are evident. Many unanswered questions remain regarding mechanisms of HIV...

2010
Edwin J Heeregrave Mark J Geels Elly Baan Renee M van der Sluis William A Paxton Georgios Pollakis

BACKGROUND Although antiretroviral therapy (ART) has proven its success against HIV-1, the long lifespan of infected cells and viral latency prevent eradication. In this study we analyzed the sensitivity to ART of HIV-1 strains in naïve, central memory and effector memory CD4+ lymphocyte subsets. METHODS From five patients cellular HIV-1 infection levels were quantified before and after initi...

Journal: :The Journal of infectious diseases 2000
E Papasavvas G M Ortiz R Gross J Sun E C Moore J J Heymann M Moonis J K Sandberg L A Drohan B Gallagher J Shull D F Nixon J R Kostman L J Montaner

Immunologic and virologic outcomes of treatment interruption were compared for 5 chronically human immunodeficiency virus (HIV)-infected persons who have maintained antiretroviral therapy-mediated virus suppression, as compared with 5 untreated controls. After a median interruption of 55 days of therapy accompanied by rebound of virus, reinitiated therapy in 4 of 5 subjects resulted in suppress...

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