BACKGROUND To measure ascorbic acid concentration in aqueous humor of patients with cataract after oral or intravenous vitamin C supplementation. METHODS Forty-two eyes of 42 patients with senile cataract who underwent uncomplicated cataract surgery were enrolled. Patients (n = 14 each) were administered oral vitamin C (2 g), intravenous vitamin C (20 g) or no treatment (control group) on the...

vitamin d deficiency is prevalent in diabetes type 2 and this vitamin may be related to insulin action. this randomized controlled trial study was done to evaluate the effect of vitamin d supplementation on glucose control and insulin resistance in patients with diabetes type 2.participants of this randomized clinical trial study consisted of 28 patients with type 2 diabetes who received 100 mi...

OBJECTIVE Overproduction of reactive oxygen species results in oxidative stress, a deleterious process that damages cell structure as well as lipids, proteins, and DNA. Oxidative stress plays a major role in various human diseases, such as oligoasthenozoospermia syndrome. MATERIALS AND METHODS We evaluated the effectiveness of antioxidant co-supplementation therapy using vitamin C, vitamin E,...

Free radicals and reactive species produced in vivo can trigger cell damage and DNA modifications resulting in carcinogenesis. Dietary antioxidants trap these species limiting their damage. The present study evaluated the role of vitamins C and E in the prevention of potentially premalignant modifications to DNA in the human stomach by supplementing patients who, because of hypochlorhydria and ...

BACKGROUND Breast cancer is the most frequently diagnosed cancer globally, and studies provide contradictory results about the possible effects of vitamin supplementation to reduce cancer risk. Our aim was to conduct a review to better investigate whether vitamin supplements given orally modify breast cancer risk. METHODS We conducted a comprehensive, systematic bibliographic search of the me...

Patients with rheumatoid arthritis have subnormal vitamin B6 status, both quantitatively and functionally. Abnormal vitamin B6 status in rheumatoid arthritis has been associated with spontaneous tumor necrosis factor (TNF)-alpha production and markers of inflammation, including C-reactive protein and erythrocyte sedimentation rate. Impaired vitamin B6 status could be a result of inflammation, a...

With the exceptions of folate for prevention of birth defects and calcium for prevention of bone disease, currently there is no evidence of benefit from vitamin or mineral supplementation in diabetic patients without underlying deficiencies. Given the recent revelations about antioxidant vitamins, it is prudent to refrain from using vitamin E, vitamin C, or vitamin A in excess of the Dietary Re...