Integrins are heterodimeric cell surface proteins that mediate both cell-cell and cell-extracellular matrix interactions. We and others recently identified cDNAs encoding a novel integrin beta subunit, beta 7, in lymphocytes. We have now detected beta 7 mRNA in mouse TK-1 T lymphoma cells, which are known to express the putative Peyer's patch homing receptor alpha 4 beta P. We used an anti-pept...

Cytoskeletal remodeling affects the shape, adhesion, and motility of cells. dynamics are modulated by matrix proteins, integrins, several cytokines in tumor microenvironment. In this scenario, signaling is activated integrins interferons, which can induce ISG15 gene expression. This encodes a ubiquitin-like protein that functions as modifier via ISGylation system. Furthermore, non-conjugated ac...

The integrin VLA-3 is a cell surface receptor, which binds to fibronectin, laminin, collagen type I and VI (Takada, Y., E. A. Wayner, W. G. Carter, and M. E. Hemler. 1988. J. Cell. Biochem. 37:385-393) and is highly expressed in substrate adherent cultures of almost all human cell types. The ligand specificity of VLA-3 and the inhibition of cell adhesion by anti-VLA-3 monoclonal antibodies sugg...

PURPOSE The severity of allergic conjunctivitis (AC) correlates with the degree of eosinophil infiltration into the conjunctiva, which is believed to be mediated by chemokines and adhesion molecules. The adhesion molecule very late antigen (VLA)-4 and its ligand, vascular cell adhesion molecule (VCAM)-1, are known to play important roles in eosinophil infiltration. However, the expression and f...

The paper studies the effect of pretreatment highly concentrated wastewater from confectionery production in a vortex layer apparatus (VLA) on its physical and chemical properties, with aim further use as substrate for dark fermentation biohydrogen. Pretreatment VLA resulted 2.6-fold increase iron content 6.5% soluble oxygen demand after 3 minutes exposure. After VLA, an acetic acid decrease co...

This review 1 is a futile attempt to cover developments in the eld of stellar radio astronomy (across the whole HR diagram) which have been innuenced by VLA observations. The VLA has completely revolutionized the eld; it can be argued that stellar radio astronomy would barely exist without the VLA. Diierent areas of physics and stellar astrophysics which can be addressed with VLA observations a...

Recent studies suggested that trafficking of hematopoietic progenitor cells is related to cell cycle status. We studied whether adhesion of progenitor cells to extracellular matrix proteins was modulated by cell cycle transit. Mobilized peripheral blood CD34+ cells were stimulated ex vivo for 48 hours with stem cell factor, flt-3 ligand, and thrombopoietin and fractionated by adhesion to fibron...

The sarcoglycan sub-complex is a protein system which plays key role in sarcolemma stabilization during muscle activity consisting of six glycosylated transmembrane proteins. Integrins play the process cell adhesion, linking extracellular matrix to actin cytoskeleton. Here we have analysed receptor for thyroid hormone, identified on αvβ3-integrin that has an important activation non-genomic act...

We examined the selective effects of interleukin (IL-5) in regulating the maturational expression of surface adhesion molecules on human eosinophils and adhesion to endothelial cells during eosinophiiopolesis in vitro. Expression of the beta 2 integrins (CD11/CD18) and the beta 1 integrin, VLA-4 (CD49d/ CD29), was assessed during development in culture with IL-3, IL-5, and granulocyte-macrophag...