Two important components that consume the majority of IT power in data centers are the servers and the Data Center Network (DCN). Existing works fail to fully utilize power management techniques on the servers and in the DCN at the same time. In this paper, we jointly consider VM placement on servers with scalable frequencies and flow scheduling in the DCN, to minimize the overall system’s powe...

Efficient provisioning of resources is a challenging problem in cloud computing environments due to its dynamic nature and the need for supporting heterogeneous applications. Even though VM (Virtual Machine) technology allows several workloads to run concurrently and to use a shared infrastructure, still it does not guarantee application performance. Thus, currently cloud datacenter providers e...

Dose-dependent pharmacokinetic of phenytoin necessitates the estimation of the maximum rate of metabolism (Vm) and the Michaelis-Menten constant (Km) in a concerned population. The aim of this study was to determine the pharmacokinetic parameters of phenytoin in a sample of Iranian patients to optimize the antiepileptic pharmacotherapy. Fourty patients who received a constant dose of phenytoin ...

Efficient provisioning of resources is a challenging problem in cloud computing environments due to its dynamic nature and the need for supporting heterogeneous applications with different performance requirements. Currently, cloud datacenter providers either do not offer any performance guarantee or prefer static VM allocation over dynamic, which lead to inefficient utilization of resources. E...

Virtualization-based server consolidation is an important technique for cost and energy reductions in data center environments and a key enabler of cloud computing. However, to ensure adequate application isolation and performance, consolidation demands runtime resource reconfiguration, especially of multi-tier services that have dynamic, rapidly changing workloads and responsiveness requiremen...

Cloud computing focuses on delivery of reliable, Fault-tolerant and scalable infrastructure for hosting Internet based application services. Cloud computing has become a new age technology that has got huge potentials in enterprises and markets. Clouds can make it possible to access applications and associated data from anywhere. Resource allocation is one of the important challenges in cloud c...

Physical isolation provides tenants in a cloud with strong security guarantees, yet dedicating entire machines to tenants would go against cloud computing’s tenet of consolidation. A fine-grained isolation model allowing tenants to request fractions of dedicated hardware can provide similar guarantees at a lower cost. In this work, we investigate the dynamic provisioning of isolation at various...

Cloud computing promises high performance and cost-efficiency. However, most cloud infrastructures operate at a low utilization, which greatly adheres cost effectiveness. Previous works focus on seeking efficient virtual machine (VM) consolidation strategies to increase the utilization of virtual resources in production environment, but overlook the under-utilization of backup virtual resources...

Virtual machine migration is an important tool that can be used in cloud computing environment for load balancing, disaster recovery, server consolidation, hardware maintenance, etc. Currently a few techniques have been proposed to secure the virtual machine migration process. However, these techniques have number of limitations e.g. lack of standard access control, mutual authentication, confi...