Purpose: To investigate the outcome of outlet-type ventricular septal defect (VSD) after surgery in pediatric patients. Methods: A total of 152 children who underwent surgical repairs for outlet-type VSD were enrolled. Clinical features associated with development of congestive heart failure (CHF), aortic valve prolapse (AVP), and aortic regurgitation (AR) were analyzed. Results: CHF was noted ...

Ventricular septal defect (VSD) is the most common congenital heart defect. Indicated closure is performed either by surgery or by using a transcatheter route in eligible patients (1). Although closure rates are similar in the transcatheter and surgical VSD closure, both the transcatheter closure of a VSD and surgery are not a complication-free procedure (2, 3). The occurrence of a complete atr...

Objective: To evaluate the outcome of surgical repair of VSD in older children and adults. Methods: It is a retrospective study of 47 patients who underwent VSD repair by the authors during a period of 5-years. The patients included 35 boys and 12 girls. The data was retrieved from the electronic database. The numeric variables were summarized as mean, median and standard deviation while the ca...

Postinfarction ventricular septal defects (VSD) represent a devastating complication of acute myocardial infarction and are associated with high mortality. Percutaneous interventional closure of postinfarction VSD has been proposed as a potential alternative to surgery. The study aimed to evaluate the therapeutic safety and efficacy of percutaneous interventional closure of postinfarction ventr...

OBJECTIVE To determine whether the proximal isovelocity surface area (PISA) method could be applied to estimate the magnitude of ventricular septal defect (VSD) shunt flow. DESIGN Prospective analysis of clinical, echocardiographic, and angiographic data. SETTING University hospital. PATIENTS 14 children with VSD. METHODS Colour Doppler images of VSD shunt flow were obtained in paraster...

Thirty (10.8%) of 279 patients undergoing correction of a ventricular septal defect (VSD) from January, 1972, to September, 1986, also had a double-chambered right ventricle (DCRV). Age at operation ranged from 1.3 to 18.8 years (mean, 6.7 +/- 4.5 years [+/- standard deviation]). Seventeen patients were male, and 13 were female. Two-dimensional echocardiography was used after 1978 in the initia...

Bifid cardiac apex is a rare anomaly of human hearts. We report of the case of a 34-year-old man with a previous history of ventricular septal defect (VSD) and subvalvular pulmonary stenosis. He had undergone pulmonary commissurotomy and VSD closure 22 years before he was referred to our center for evaluation of progressive dyspnea. Transthoracic echocardiography revealed atrial septal defect (...

KCNQ1 (also known as KV7.1 or KVLQT1) is a voltage-gated potassium channel modulated by members of the KCNE protein family. Among multiple functions, KCNQ1 plays a critical role in the cardiac action potential. This channel is also subject to inherited mutations that cause certain cardiac arrhythmias and deafness. In this study, we report the overexpression, purification, and preliminary struct...

OBJECTIVE To assess and evaluate the effectiveness of early ventricular septal defect (VSD) repair in a developing country by comparing the outcomes in two age groups. METHODS A total of 39 patients underwent VSD repair at a tertiary care hospital in Karachi over a period of 2.5 years. Patients were divided into Group 1 (<2 years) and Group 2 (2-18 yrs). Perioperative and postoperative variab...

Congenital heart disease (CHD) is the most common birth defect in humans. Genetic causes and underlying molecular mechanisms for isolated CHD remain largely unknown. Studies have demonstrated that GATA transcription factor 6 (GATA6) plays an essential role in the heart development. Mutations in GATA6 gene have been associated with diverse types of CHD. As GATA6 functions in a dosage-dependent m...