The Food and Drug Administration (FDA) creates the climate for the development of new drugs and clinical research. A 30 year struggle to bring drugs to the market more rapidly culminated in the 1992 Prescription Drug User Fee Act (PDUFA). While drug review times have shortened, concerns about drug safety possibly associated with more rapid reviews have led FDA and Congress to tighten safety req...

1Department of Nuclear Medicine, University of Cologne, Cologne, Germany; 2German Hodgkin Study Group, University of Cologne, Cologne, Germany; 3Department of Clinical Hematology, Third Faculty of Medicine, Charles University, Prague, Czech Republic; 4Schweizer Arbeitsgruppe für Klinische Krebsforschung, Bern, Switzerland; 5Klinik für Strahlenheilkunde, Charité-Universitätsmedizin Berlin, Campu...

The solar chromosphere consists of three classes plage, network, background which contribute differently to ultraviolet radiation reachina thn am-th ~.nl~r nhv&-iota cama intmwatd in --a “Y” U-V.&. Y”*yYJ”.“‘uY” .“A.8 .Y”YIVY”VU IY relating plage area and intensity to UV irradiante, as well as understanding the spatial and temporal evolution of plage shapes. We describe a data set of solar imag...

1 Departments of Functional Genomics and Clinical Genetics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, Vrije Universiteit (VU) and VU Medical Center, 1081 HV Amsterdam, Netherlands 2 Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Goettingen, Germany 3 Department of Genetics and Medicine, University of Pennsylvania,...

As scoliotic curve is a rotational deformity, derotation maneuvre was used as the corrective factor, but recent studies demonstrated spinal imbalance and decompensation problems in patients treated with this method. This study evaluates 217 late onset idiopathic scoliosis patients surgically treated with third generation instrumentation (Texas Scotish Rite Hospital System - TSRH) from September...