Nerve agents pose a threat to the respiratory tract with exposure that could result in acute compromised lung performance and death. The determination of toxicity by inhalation is important for the rational development of timely therapeutic countermeasures. This study was designed to deliver aerosolized dilute nerve agents in a dose-response manner to investigate the extent of lethality of nerv...

The CFTR gene contains 27 exons and is located at position 31.1 of the long arm chromosome 7 (7q31.1). More than 2000 variants have been described so far. R334W variant associated with mild disease course. Objective. To perform comprehensive assessment health status, functional activity, efficacy modulators in twins F508del/R334W genotype. Materials methods. Data from medical records, intestina...

Chemical agents pose a significant threat to social security, highlighting the crucial role of representative chemical adsorption in ensuring safety our environment. This study explored application Magnetic Graphene Oxide Nanoplatelet Composites (MGONCs) adsorbing such as Lewisite (L), O-ethyl S-2-diisopropylaminoethyl methylphosphonothiolate (VX), Sarin (GB), and Soman (GD). MGONCs were synthe...

V-type nerve agents, known as VX, are organophosphate (OP) compounds, and show extremely toxic effects on human and animals by causing cholinergic overstimulation of synapses. The bacterial organophosphorus hydrolase (OPH) has attracted much attention for detoxifying V-type agents through hydrolysis of the P-S bond. However, low catalytic efficiency of OPH has limited the practical use of the e...

A novel method for the rapid screening of degradation products derived from nerve agents by matrix-assisted laser desorption ionization time-of-flight mass spectrometry is described. Five standard products were selected as model compounds, including isopropyl methylphosphonic acid (IMPA), pinacolyl methylphosphonic acid (PMPA), ethyl methylphosphonic acid (EMPA), isobutyl methylphosphonic acid ...

Current conveyors are unity gain analog building block having high linearity, wide dynamic range and provide higher gain-bandwidth product. The current conveyors operate at low voltage supplies and consume less power. It has high input impedance, low output impedance and unity current gain (Iz/Ix=±1) as well as unity voltage gain (Vx/Vy=1). The working principle of Current Conveyors is very sim...