The PRH/Hhex transcription factor represses multiple genes in the VEGF signalling pathway (VSP) to inhibit myeloid cell survival. Protein kinase CK2 phosphorylates PRH and counteracts the inhibitory effect of this protein on cell survival by blocking the repression of VSP genes. Here we show that the BCR-ABL/Src kinase inhibitor dasatinib decreases PRH phosphorylation and increases PRH-dependen...

The ability of MicroScan rapid panels (Baxter MicroScan, West Sacramento, Calif.) to detect oxacillin resistance in 92 clinical isolates of Staphylococcus aureus and 103 coagulase-negative staphylococci was evaluated by comparing results with those of MicroScan 24-h MIC panels and, to resolve discrepancies, oxacillin agar screening. Both panels were interpreted by the MicroScan WalkAway-96 syst...

RESULTS AND CONCLUSION: The challenge of craniopagus separation is due to the complexity of the venous plexus and shared dural venous sinus. Therefore, separation of the venous system of the twins requires meticulous planning and stereoscopic appreciation of the vasculature. Both VSP and 3D printed models were critical as references of the venous anatomy during separation and to the survival of...

We study a hedge fund style contract in which management fees, incentive fees and a high water mark provision drive a fund manager’s effort and risk choices as well as walkaway decisions by both the fund manager and the investor. We model this relationship and calibrate the model to observed data. The model yields empirical predictions regarding the impact of a fund’s distance from the high wat...

Background: Craniomaxillofacial (CMF) injuries has different patterns from simple to complicated ones. Surgeons usually spend time and effort planning the optimal surgical approach avoid damage vital structures that could otherwise lead functional deficits. It is also imperative optimize skin incisions unfavourable scarring. The aim of this work assess effectiveness efficiency virtual (VSP) app...

Vehicle emissions intensity at a given travel speed is well known among the public since key parameter in both traffic model and emission model. Yet, several problems still remain traditional approaches of measuring intensity. To establish accurate high-resolution factors, an established method factors proposed based on real-time monitoring operation conditions data, which can reflect effect dy...

An efficient software tool for investigations on novel stacked gate dielectrics with emphasis on reliability has been developed. The accumulation, depletion, and inversion of carriers in MOS capacitors is properly considered for nand p-substrates. The effect of carrier quantization on the electrostatics and the leakage current is included by treating carriers in quasi-bound states (QBS) and con...

Abstract This paper, considers the channel estimation problem of uplink low Earth orbit (LEO) satellite orthogonal frequency division multiplexing (OFDM) system. By exploiting structured sparsity in delay‐Doppler‐angle domain, is formulated as a block‐sparse signal recovery problem. The variance state propagation (VSP) framework extended to solve such Considering that delay, Doppler shift, and ...