The purpose of this study was to investigate the temperature-induced crystallization and the compactibility of the composite particles containing amorphous lactose and various types of polymers. The composite particles were prepared by spray-drying an aqueous solution of lactose and various types of gel forming water-soluble polymers at various formulating ratios. The stabilizing effect of hydr...

Oral route is the most preferred route for administration of different drugs because it is regarded as safest, most convenient, and economical route. Fast disintegrating tablets are very popular nowadays as they get dissolved or facilely disintegrated in mouth within few seconds of administration without the need of water. The disadvantages of conventional dosage form, especially dysphagia (ard...

Objectives: The aim of the present study was to evaluate effects of various polymers on the release of a water soluble drug by using spray drying technique of microencapsulation. Methods: Spray drying is a single step technique, less time is required and loading efficiency is not affected by the nature of the drug whether hydrophilic or hydrophobic. Eudragit RS 30D, RL 30D and Ethylcellulose (S...

Rationally encoding molecular interactions that can control the assembly structure and functional expression in a solution of conjugated polymers hold great potential for enabling optimal organic optoelectronic and sensory materials. In this work, we show that thermally-controlled and surfactant-guided assembly of water-soluble conjugated polymers in aqueous solution is a simple and effective s...

This review focuses on nontemplate-dependent polymerases that use water-soluble substrates and convert them into water-insoluble polymers that form granules or inclusions within the cell. The initial part of the review summarizes briefly the current knowledge of polymer formation catalyzed by starch and glycogen synthases, polyphosphate kinase (a polymerase), cyanophycin synthetases, and rubber...

Ion-specific solvation has fundamental implications in biochemistry, and the thermodynamics and dynamics of aqueous salt solutions have correspondingly been investigated intensively. Nonetheless, there are fundamental unresolved issues in modeling the dynamics of aqueous salt solutions and the related problem of polymers dissolved in these solutions. In particular, experiments show that the sel...

An amphiphilic phosphodiester-linked azobenzene trimer has been exploited in the development of stimuli-responsive, water-soluble supramolecular polymers. The can reversibly undergo thermal and photoisomerization between Z- E-isomers. Its self-assembly properties aqueous medium have investigated by spectroscopic microscopic techniques, demonstrating that E- Z-azobenzene trimers form nanosheets ...

Hydrophilic polymers alone are not quite efficient in controlling the release of highly water soluble drugs. Hydrophobic Polymer and pore forming agent have been extensively investigated for sustaining the release of drug. They provide several advantages include good stability at varying pH ranges and effectively retards the water soluble drug. In the present study it was a novel approach where...

Poly([stearyl methacrylate]-stat-[2-(dimethylamino) ethyl methacrylate]) was synthesised through radical polymerisation using 1,1-diphenyl ethylene (DPE) as a molecular weight controlling agent. The amino groups were further quaternised into a cationic form in order to increase water solubility. Solubility of the polymers in water and a mixed solvent was studied with rotational rheometry. The r...

Some bacterial genomes were found to contain genes encoding putative proteins with considerable sequence homology to cyanophycin synthetase CphA of cyanobacteria. Such a gene from the Gram-positive, spore-forming anaerobe Desulfitobacterium hafniense was cloned. Expression in Escherichia coli resulted in the formation of a polydispers copolymer of aspartic acid and arginine, with a minor amount...