BACKGROUND Pembrolizumab is an anti-programmed death 1 (PD-1) receptor monoclonal antibody that has shown activity as second line treatment for metastatic head and neck squamous cell carcinoma (HNSCC). Immune-related adverse events are now well described complications of PD-1 inhibitors and most organ sites have been shown to be potentially affected. CASE PRESENTATION We describe a 69-year ol...

We report a case of bead shedding from a cylindrical extensively porous-coated cementless femoral component with concomitant taper corrosion at the modular head-neck junction of a metal-on-polyethylene total hip prosthesis. The patient presented with chronic thigh pain 4 years after primary total hip arthroplasty, and radiographs revealed significant osteolysis and metallic debris around the fe...

The aim of this study was to assess responses to taper in elite athletes using computer simulations. Parameters of a non-linear model were derived from training and performance data over two seasons for eight elite swimmers. The fit between modelled and actual performances was statistically significant for each swimmer (r(2) = 0.56 +/- 0.06; P < 0.01). The simulations were used to estimate char...

BACKGROUND Material loss at the taper junction of metal-on-metal total hip arthroplasties has been implicated in their early failure. The mechanisms of material loss are not fully understood; analysis of the patterns of damage at the taper can help us better understand why material loss occurs at this junction. METHODS We mapped the patterns of material loss in a series of 155 metal-on-metal ...

Background: GiACTA investigated tocilizumab (TCZ) for the treatment of giant cell arteritis (GCA). Objectives: To investigate disease flare characteristics after successful with TCZ in GiACTA. Methods: We report a post hoc analysis from part 2 Part 1 was 52-week, double-blind, randomized controlled period and 2-year open-label follow-up. In 1, patients received 162 mg subcutaneously every week ...