A new method for detecting DNA-protein cross-links involving selective precipitation of DNA containing cross-linked proteins by k -sodium dodecyl sulfate was utilized in the peripheral WBC of 21 male metal arc welders and in 26 male controls of similar age and racial characteristics who were not exposed to welding fumes. DNA was quantitated by Hoechst fluorescence. Although the concentration of...

Personnel records of over 1000 welders and electricians but only 235 caulkers and 557 platers employed at a shipyard in NE England between 1940 and 1968 were obtained and the mortality followed up to December 1982. The observed number of deaths (13 from mesothelial tumours, nine among the electricians) were compared with the number to be expected in the Newcastle connurbation. Welders and caulk...

Humans are exposed to nanoparticles (NPs; diameter < 100 nm) from ambient air and certain workplaces. There are two main types of NPs; combustion-derived NPs (e.g., particulate matters, diesel exhaust particles, welding fumes) and manufactured or engineered NPs (e.g., titanium dioxide, carbon black, carbon nanotubes, silver, zinc oxide, copper oxide). Recently, there have been increasing report...

BACKGROUND Welders exposure to nickel and hexavalent chromium in welding fumes is associated with increase of cancer risk in welders. In this study we calculated cancer risk due to exposure to these compounds in welders. METHODS The role of exposure parameters in welders on derived incremental lifetime cancer risk were determined by stochastic modeling of cancer risk. Input parameters were de...

large amounts of aluminum-containing particles are introduced into the respiratory tract.18’19 While metallic aluminum and M203 dusts seem to have a fibrogenic potential in the lungs, the risk in most occupational settings is believed to be small. The patient described in this report worked in confined quarters aboard ship, where he was exposed exelusively to aerosols of oxidized aluminum. Conc...

A new method for detecting DNA-protein cross-links involving selective precipitation of DNA containing cross-linked proteins by k -sodium dodecyl sulfate was utilized in the peripheral WBC of 21 male metal arc welders and in 26 male controls of similar age and racial characteristics who were not exposed to welding fumes. DNA was quantitated by Hoechst fluorescence. Although the concentration of...

INTRODUCTION There is growing interest in preventable, non-smoking causes of chronic obstructive pulmonary disease (COPD), among which are chronic exposures to respiratory irritants in the workplace. SOURCES OF DATA Reviews of occupational COPD in specific occupations and industries and in general populations; supplemented with other or more recently published material. AREAS OF AGREEMENT T...

Chronic exposure to high concentrations of fumes during aluminum arc welding causes a severe pneumoconiosis characterized by diffuse pulmonary accumulation of aluminum metal and a corresponding reduction in lung function. Aluminum fume-induced pneumoconiosis is a rarely reported entity, of which the true incidence is unknown. We report the clinical, radiographic, microscopic, and microanalytic ...