Cell-penetrating peptides and proteins (CPPs) are important tools for the delivery of impermeable molecules into living mammalian cells. To enable these cells to internalize proteins fused to common oligohistidine affinity tags, we synthesized an artificial cell surface receptor comprising an N-alkyl derivative of 3beta-cholesterylamine linked to the metal chelator nitrilotriacetic acid (NTA). ...

existence of suffering in life is undeniable. but, why does suffering exist? what is its cause? are there any meanings for this life? is it possible to escape from suffering? dostoyevsky, who believes that suffering is an inherent element of human life, tries to represent the problem of suffering and men's reactions to it in his works. he believes that not only suffering does exist, but al...

The articles in this special issue explore approaches to research and action language education that have the potential transform subjectivities practices relation linguistic diversity. They seek ways within teacher overcome what Gogolin ([1994]. Der monolinguale ‘habitus’ der multilingualen Schule. Waxmann Verlag) called ‘mononlingual habitus’, i.e. deep-seated habit of assuming monolingualism...

ahmad showqi is one of the outstanding contemporary poets and had such an important state among the poets who were called poet laureate. quran played as a spring which he enjoyed it a lot for his poetry. by studying his poetry we come to conclusion that holy quran had a significant effect on showqi’s poetry and he had used its vocabulary and semantics in all his poetry. doomsday and its images ...

Tuftelin is an acidic protein expressed at very early stages of mouse odontogenesis. It was suggested to play a role during epithelial-mesenchymal interactions, and later, when enamel formation commences, to be involved in enamel mineralization. Tuftelin was also detected in several normal soft tissues of different origins and some of their corresponding cancerous tissues. Tuftelin is expressed...

We study the relationship between l-groups, Bézout domains, and MV -algebras. Our main motivation and starting point has been the Jaffard-Ohm correspondence between Abelian l-groups and Bézout domains ¶ μ 3 ́ Bézout domains with non-zero unit radical ¶ μ 3 ́ Unital l-groups ¶ μ 3 ́ MV -algebras ©© ©© ©© © HHHHHH ——————————– and Mundici’s equivalence between Abelian unital l-groups and MV -algebras...

The OpuA system of Bacillus subtilis is a member of the substrate-binding-protein-dependent ABC transporter superfamily and serves for the uptake of the compatible solute glycine betaine under hyperosmotic growth conditions. Here, we have characterized the nucleotide-binding protein (OpuAA) of the B.subtilis OpuA transporter in vitro. OpuAA was overexpressed heterologously in Escherichia coli a...

Human calprotectin (CP) is a metal-chelating antimicrobial protein of the innate immune response. The current working model states that CP sequesters manganese and zinc from pathogens. We report the discovery that CP chelates iron and deprives bacteria of this essential nutrient. Elemental analysis of CP-treated growth medium establishes that CP reduces the concentrations of manganese, iron and...