We report that transfusions of RT1u Wistar-Furth (WF) spleen cells prevented spontaneous diabetes in the RT1u BB/W rat while RT1b Buffalo rat spleen cells did not. In addition, donor origin WF T lymphocytes were detected in nondiabetic-susceptible BB/W recipients 5 mo after transfusion. Survival of donor-origin lymphocytes may provide the cellular mechanism by which major histocompatibility com...

Objective: In addition to attention deficits and hyperactivity it is common for children with ADHD to display impaired fine and gross motor skills. The spontaneously hypertensive (SH) rat model of ADHD displays impaired motor learning [1]. We used this characteristic to study if the recently described acoustic noise benefit in learning in children with ADHD [2, 3] is also observed in the SH ra...

Regenerating (REG) proteins are associated with islet development, β-cell damage, diabetes and pancreatitis. Particularly, REG-1 and REG-3-beta are involved in cell growth/survival and/or inflammation and the Reg1 promoter contains interleukin-6 (IL-6)-responsive elements. We showed by transcriptome analysis that islets of Goto-Kakizaki (GK) rats, a model of spontaneous type 2 diabetes, overexp...

Background: Male infertility is considered a major cause of couple as it represents 25- 50 % cases. In addition, non-obstructive azoospermia (NOA) 10% all infertile men.There no definite curable treatment for such cases.
 Aim Work: The purpose this research was to assess the efficacy BM-MSCs and AT-MSCs in treating busulfan-induced wistar rats.
 Materials Methods: were extracted from ...

There is a claim that using medicinal plants carelessly can be dangerous. The consequences of consuming numerous these over time on the brain have remained mystery. Alfavaca one such herbs commonly used in Nigeria. This research was done to find out how leaf extract affected hippocampus wistar rats had been exposed lead acetate. were five (5) groups twenty-five (25) Wistar rats, each with rats....

background: poly cystic ovary syndrome is one of the most common female endocrine disorders. one of the side effects of pcos is oxidative stress.. here we investigated antioxidants effects of thymus vulgaris ethanoli extract on experimental pcos induced rats by estradiol-valerat (ppa). methods : wistar female rat (n=70) were divided into 7 groups including c1: an equal volume of (0.9% nacl) as ...

Objective(s): Intracerebral injection of bone marrow stromal cells (BMSCs) is being investigated as a therapeutic tool to prevent Alzheimer's disease (AD). Our aim was to investigate the effects of BMSCs by intrathecal injection in AD rat model. Materials and Methods: BMSCs were obtained from the bone marrow of Wistar rat and transplanted into AD rat model via intrathecal injection. The rat mod...