The activities of mining exploitation in Campo de Jales were performed in an uncontrolled way and gave rise to serious environmental contamination: rubbish depositories have been accumulated with no treatment or maintenance. An investigation developed around Jales Mine showed the existence of some chemical impact originated from the waste produced during mining activities. Some "black spots" fo...

We study the effect of topology variation on the dynamic behavior of a system with local update rules. We implement one-dimensional binary cellular automata on graphs with various topologies by formulating two sets of degree-dependent rules, each containing a single parameter. We observe that changes in graph topology induce transitions between different dynamic domains (Wolfram classes) withou...

Wolfram-like syndrome (WFSL) is a rare autosomal dominant disease characterised by congenital progressive hearing loss, diabetes mellitus, and optic atrophy. The patient was a boy with the juvenile form of diabetes mellitus and findings which clinically matched the symptoms of Wolfram syndrome. At the age of 3 1/4 years, diabetes mellitus was diagnosed in this boy who also had severe psychomoto...

Deficiency of the protein Wolfram syndrome 1 (WFS1) is associated with multiple neurological and psychiatric abnormalities similar to those observed in pathologies showing alterations in mitochondrial dynamics. The aim of this study was to examine the hypothesis that WFS1 deficiency affects neuronal function via mitochondrial abnormalities. We show that down-regulation of WFS1 in neurons leads ...

Glossary Cellular Automaton For our purposes, a (one-dimensional) cellular automaton (CA) is given by a local map ρ : Σ → Σ where Σ is the underlying alphabet of the automaton and w is its width. As a data structure, suitable as input to a decision algorithm, a CA can thus be specified by a simple lookup table. We abuse notation and write ρ(x) for the result of applying the global map of the CA...

this study was carried out for the purpose of investigating the issue of tailings dams as a potential source of contamination by trace elements in soils at the sidi bou othmane mine in the marrakech region, morocco. soil samples taken from depths of up to 15 cm and within a radius of 50 m from the tailings dams, were analyzed for cd, cu, pb and zn using atomic absorption spectrometry. average c...

Wolfram syndrome is the condition characterized by juvenile onset diabetes mellitus and optic atrophy, which also known as DIDMOAD. Classical a rare autosomal recessive disorder caused mutations in WFS1, gene involved endoplasmic reticulum mitochondrial function. Patients present with type 1 followed atrophy first decade, insipidus sensorineural deafness second dilated renal outflow tracts earl...

Metal price is one of the most important parameters in the calculation of cut- off grade. The cut- off grade has the main role in determination of mine layout. Mine layout actuates mineable reserve, mine life and economic profitability. Not considering the uncertainty in metal prices can lead to a non-optimal layout. In this paper optimum underground mine layout is determined by expected utilit...

Wolfram syndrome is a neurodegenerative disorder caused by pathogenic variants in the genes WFS1 or CISD2. Clinically, classic phenotype composed of optic atrophy, diabetes mellitus type 1, insipidus, and deafness. syndrome, however, phenotypically heterogenous with variable clinical manifestations age onset. We describe four cases genetically confirmed presentations, including acute-on-chronic...